Could a Triple-Drug combo tame mesothelioma?

NCT ID NCT01064648

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 4 times

Summary

This study tests whether adding the drug cediranib to standard chemotherapy (cisplatin and pemetrexed) can help people with malignant pleural mesothelioma, a rare and aggressive lung cancer. In the first phase, researchers found the safest dose of cediranib. In the second phase, they compare the three-drug combo against chemo alone to see if it delays cancer growth. The trial enrolled 117 people who had not received prior treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

117 people

The number who actually took part.

Started

Mar 2010

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must have histologically or cytologically confirmed diagnosis of malignant pleural mesothelioma; surgical resection must not be planned * Patients must have measurable or non-measurable disease by both RECIST and modified RECIST criteria for pleural tumors as documented by computed tomography (CT) scan; examinations for assessment of measurable disease must have been completed within 28 days prior to registration; examinations for assessment of non-measurable disease must have been performed within 42 days prior to registration; all disease must be assessed and documented on the RECIST 1.1 and Modified RECIST Baseline Tumor Assessment Form * Patients must not have received any prior systemic therapy (chemotherapy or other biologic therapy) for their unresectable malignant pleural mesothelioma; prior systemic chemotherapy or biologic therapy is allowed as neoadjuvant or adjuvant treatment, disease has now recurred, and all systemic treatment was completed \> 6 months prior registration; prior therapy must not have included cediranib * Patients may have received prior surgery (e.g., pleurectomy, pleurodeisis) provided at least 28 days have elapsed since surgery (thoracic or other major surgeries) and patients have recovered from all associated toxicities at the time of registration; there must be no anticipated need for major surgical procedures during protocol treatment * Patients may have received prior radiation therapy provided at least 28 days have elapsed since the last treatment and patients have recovered from all associated toxicities at the time of registration * Institutions must seek additional patient consent for the banking and future use of specimens * Patient must have Zubrod performance status 0-2 * Absolute neutrophil count \>= 1,500 mcl * Platelets \>= 100,000/ml * Hemoglobin \>= 9.0 g/dl (may be reached by transfusion) * Total bilirubin =\< 1.5 x institutional upper limit of normal (IULN) * Serum glutamic oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT) =\< 2.5 x ULN (if liver metastases are present, SGOT or SGPT must be =\< 5.0 x IULN) * Serum creatinine =\< 1.5 x IULN * Calculated creatinine clearance \>= 60 mL/min * Urine protein must be screened by urine analysis within 28 days prior to registration; patient must not have greater than +1 proteinuria on two consecutive dipsticks taken no less than 7 days apart; however, if the first urinalysis shows no protein, then a repeat urinalysis is not required * Patient must have an electrocardiogram (ECG) performed within 42 days prior to registration; patient must not have mean corrected QT (QTc) \> 500 msec (with Bazett's correction) in screening electrocardiogram, or other significant ECG abnormality, New York Heart Association (NYHA) classification III or IV; patient must not require concurrent use of drugs or biologics with proarrhythmic potential * Patient must not be receiving any medication that may markedly affect renal function (e.g., vancomycin, amphotericin, pentamidine) * Patient must not have had clinically significant hemoptysis, defined as greater than 1 tablespoon of bright red blood, within one year prior to registration; although hemoptysis has not been associated with cediranib, it may be a class effect for anti-angiogenic agents and therefore a risk factor for this experimental agent * Patient must be able to swallow oral medications * Patients must not have known human immunodeficiency virus (HIV) infection * Patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures * Patient must have no plans to receive concurrent chemotherapy, hormonal therapy, radiotherapy, immunotherapy or any other type of therapy for treatment of cancer while on this protocol treatment * No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years

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Conditions

The condition(s) this trial relates to.

malignant epithelioid mesothelioma malignant mesothelioma malignant pleural mesothelioma Mesothelioma, Malignant sarcomatoid mesothelioma Solitary Fibrous Tumor, Pleural

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epithelioid mesothelioma Pleural malignant mesothelioma Recurrent malignant mesothelioma Sarcomatoid mesothelioma

Contacts and locations

Locations

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Allegiance Health

Jackson, Michigan, 49201, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Ballad Health Cancer Care - Kingsport

Kingsport, Tennessee, 37660, United States
Ballad Health Cancer Care - Norton

Norton, Virginia, 24273, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Big Horn Basin Cancer Center

Cody, Wyoming, 82414, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bristol Regional Medical Center

Bristol, Tennessee, 37620, United States
Cancer Care Center at Island Hospital

Anacortes, Washington, 98221, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Northwest - Spokane South

Spokane, Washington, 99202, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Castle Medical Center

Kailua, Hawaii, 96734, United States
Central Illinois Hematology Oncology Center

Springfield, Illinois, 62702, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Columbus NCI Community Oncology Research Program

Columbus, Ohio, 43215, United States
Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Missoula, Montana, 59804, United States
Compass Oncology Vancouver

Vancouver, Washington, 98684, United States
Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124, United States
Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas, 66606, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Danville Regional Medical Center

Danville, Virginia, 24541, United States
Dayton NCI Community Oncology Research Program

Dayton, Ohio, 45459, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015, United States
Delaware Radiation Oncology

Delaware, Ohio, 43015, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Evergreen Hematology and Oncology PS

Spokane, Washington, 99218, United States
FHCC at EvergreenHealth

Kirkland, Washington, 98034, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States
Franciscan Saint Francis Health-Beech Grove

Beech Grove, Indiana, 46107, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Genesys Regional Medical Center-West Flint Campus

Flint, Michigan, 48532, United States
Glacier Oncology PLLC

Kalispell, Montana, 59901, United States
Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grandview Hospital

Dayton, Ohio, 45405, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greene Memorial Hospital

Xenia, Ohio, 45385, United States
Greenville Health System Cancer Institute-Andrews

Greenville, South Carolina, 29601, United States
Harborview Medical Center

Seattle, Washington, 98104, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States
Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Highlands Oncology Group - Rogers

Rogers, Arkansas, 72758, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Iredell Memorial Hospital

Statesville, North Carolina, 28677, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688, United States
Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States
Kaiser Permanente Sacramento Medical Center

Sacramento, California, 95825, United States
Kaiser Permanente San Leandro

San Leandro, California, 94577, United States
Kaiser Permanente Washington

Seattle, Washington, 98112, United States
Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States
Kaiser Permanente-Fremont

Fremont, California, 94538, United States
Kaiser Permanente-Fresno

Fresno, California, 93720, United States
Kaiser Permanente-Modesto

Modesto, California, 95356, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Redwood City

Redwood City, California, 94063, United States
Kaiser Permanente-Richmond

Richmond, California, 94801, United States
Kaiser Permanente-Roseville

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-San Rafael

San Rafael, California, 94903, United States
Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Stockton

Stockton, California, 95210, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Kuakini Medical Center

Honolulu, Hawaii, 96817, United States
Lake Huron Medical Center

Port Huron, Michigan, 48060, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States
Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Matthews Radiation Oncology Center

Matthews, North Carolina, 28105, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan, 48106, United States
Minor and James Medical PLLC

Seattle, Washington, 98104, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Montana Cancer Consortium NCORP

Billings, Montana, 59102, United States
Montana Cancer Specialists

Missoula, Montana, 59802, United States
Mount Carmel East Hospital

Columbus, Ohio, 43213, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
Newark Radiation Oncology

Newark, Ohio, 43055, United States
Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia, 30501, United States
Novant Health Cancer Institute - Huntersville

Huntersville, North Carolina, 28078, United States
Novant Health Cancer Institute - Matthews

Matthews, North Carolina, 28105, United States
Novant Health Cancer Institute - Mooresville

Mooresville, North Carolina, 28117, United States
Novant Health Carolina Surgical - Randolph

Charlotte, North Carolina, 28207, United States
Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States
OSF Saint Joseph Medical Center

Bloomington, Illinois, 61701, United States
OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903, United States
OhioHealth Marion General Hospital

Marion, Ohio, 43302, United States
Oncology Hematology Care Inc-Anderson

Cincinnati, Ohio, 45230, United States
Oncology Hematology Care Inc-Blue Ash

Cincinnati, Ohio, 45242, United States
Oncology Hematology Care Inc-Crestview

Crestview Hills, Kentucky, 41017, United States
Oncology Hematology Care Inc-Eden Park

Cincinnati, Ohio, 45202, United States
Oncology Hematology Care Inc-Healthplex

Fairfield, Ohio, 45014, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Oncology Hematology Care Inc-Mercy West

Cincinnati, Ohio, 45211, United States
Oncology Specialists of Charlotte

Charlotte, North Carolina, 28207, United States
Orlando Health Cancer Institute

Orlando, Florida, 32806, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Prisma Health Greenville Memorial Hospital

Greenville, South Carolina, 29605, United States
Providence Milwaukie Hospital

Milwaukie, Oregon, 97222, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Radiation Oncology of Northern Illinois

Ottawa, Illinois, 61350, United States
Reid Health

Richmond, Indiana, 47374, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rockwood Clinic

Spokane, Washington, 99220, United States
Rocky Mountain Oncology

Casper, Wyoming, 82609, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States
Saint Joseph Medical Center Hematology and Oncology - Silverdale

Silverdale, Washington, 98383, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Peter's Community Hospital

Helena, Montana, 59601, United States
Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Saint Vincent Healthcare

Billings, Montana, 59101, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
Singing River Hospital

Pascagoula, Mississippi, 39581, United States
Skagit Valley Hospital

Mount Vernon, Washington, 98274, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Southeast Clinical Oncology Research Consortium NCORP

Winston-Salem, North Carolina, 27104, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Southern Oncology Specialists-Charlotte

Charlotte, North Carolina, 28262, United States
Southern Oncology Specialists-Huntersville

Huntersville, North Carolina, 28078, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Strecker Cancer Center-Belpre

Belpre, Ohio, 45714, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660, United States
Wellmont Medical Associates Oncology and Hematology-Bristol

Bristol, Tennessee, 37620, United States
Wellmont Medical Associates Oncology and Hematology-Johnson City

Johnson City, Tennessee, 37604, United States
Wenatchee Valley Hospital and Clinics

Wenatchee, Washington, 98801, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

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