Could a cannabis compound help ADHD? new trial tests CBG
NCT ID NCT06115603
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests whether a single dose of cannabigerol (CBG), a non-psychoactive cannabis compound, can improve attention and reduce hyperactivity in adults with ADHD. 76 participants will receive either 80mg of CBG or a placebo, then complete computer and paper tasks measuring focus, memory, and decision-making. The study aims to see if CBG offers a new way to ease ADHD symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cannabigerol (CBG)
- What this could lead to
- If it works, this could point toward a new, non-stimulant option for easing ADHD symptoms like inattention and impulsivity.
- What could go wrong
- This is a small, early-phase trial testing only a single dose. It may show no benefit over placebo, and long-term safety and effectiveness are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 76 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2024
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1. Between 18 and 55-years-old. 2. BMI between 18 and 35 kg/m2. 3. Score a 4 or above on the Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist Part A. 4. Meet diagnostic criteria for ADHD with a current severity rating of at least mild as defined by the DIAMOND. 5. Are not pregnant or currently breastfeeding. 6. Have no history of significant allergic condition, hypersensitivity, or allergic reactions to cannabis, cannabinoid medications, hemp products, medium chain triglyceride oil, or peppermint. 7. Have not used CBG or any other cannabinoid products in the past 30 days. 8. Willing to abstain from using cannabis or any THC-containing product for the duration of the study. 9. Have never used a synthetic cannabinoid or cannabinoid analogue (e.g., dronabinol, nabilone), or a synthetic cannabinoid receptor agonist (e.g., spice, k2). 10. Have not been exposed to any investigational drug or device 30 days prior to screening and you have no plans to take an investigational drug during the study. 11. Willing to maintain a stable treatment regimen (i.e., no change in current medication use) for the duration of the study. 12. Not currently taking a prescription medication for ADHD and have not been prescribed a medication for ADHD in the past six months. 13. Not currently having thoughts of committing suicide 14. Does not meet criteria for current severe major depressive disorder or a substance use disorder. 15. Have not been diagnosed with bipolar disorder or psychosis. 16. Do not have an acute illness, such as a respiratory infection or other illness that would interfere with study participation; not currently taking medication for an acute illness (e.g., antibiotic). 17. Do not have history of diagnosis related to liver function and/or significantly impaired liver function (e.g., cirrhosis of the liver, hepatitis). 18. Willing to ensure they have used effective contraception (for example, oral contraception, double barrier, intra-uterine device) for 30 prior to the study and for 30 days after study completion. 19. Have access to a ride to the University of Arkansas campus for research appointments. 20. Willing to comply with current university mandates as they pertain to COVID-19 protocols (e.g., mask wearing). 21. Do not have any serious or unstable physical health conditions including neurological or renal illness. 22. Do not have any current or historical cardiovascular conditions, including hypotension, bradycardia, or heart block. 23. No atrial fibrillation, bradycardia, or tachycardia detected via mobile electrocardiogram during the in-laboratory visit. 24. No recent illicit drug use other than cannabis, or alcohol use in the 12 hours preceding the in-laboratory visit. 25. Not currently prescribed or taking the following medications: * Warfarin * Clobazam * Valproic acid * Phenobarbital * Mechanistic Target of Rapamycin \[mTOR\] Inhibitors * Oral tacrolimus * St. John's wort * Epidiolex * Escitalopram * Cardiovascular medications * Strong CYP3A4 inhibitors (e.g., ketoconazole)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Arkansas
RECRUITINGFayetteville, Arkansas, 72703, United States
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