CBD vs. Late-Night exercise: sleep savior or hype?
NCT ID NCT07570472
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether taking CBD before bed can improve sleep quality after a late evening high-intensity workout. Twenty healthy adults will each complete a rest session and two exercise sessions, receiving either CBD or a placebo. Sleep is measured overnight using brain-wave monitoring to see if CBD helps offset the sleep disruption caused by exercising close to bedtime.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cannabidiol (CBD)
- What this could lead to
- If it works, this could point toward a natural supplement to help people sleep better after late-night workouts.
- What could go wrong
- This is a small early-phase trial with only 20 participants, so results may not apply to everyone. CBD may not improve sleep efficiency more than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures 2. Use of highly effective methods of birth control during the entire trial and for up to 4 months after the last dose of CBD; defined as those that, alone or in combination, result in low failure rate (i.e., less than 1% per year) when used consistently and correctly; such as implants, injectables, combined oral contraceptives, some IUDs, true sexual abstinence (i.e. refraining from heterosexual intercourse during the entire period of risk associated with the Trial treatment(s)) or commitment to a vasectomised partner. 3. Age between 18-40 years old at the time of signing the Informed Consent Form (ICF) 4. Recreationally active (between 2-8h/wk) 5. Good health status confirmed by a sport medical screening 6. Body fat percentage below 20% (males) or 25% (females) as estimated by a Dual-energy X-ray absorptiometry (DXA) scan 7. Good sleep efficiency determined by the Pittsburgh Sleep Quality Index (PSQI, score ≤ 4) Exclusion Criteria: 1. Self-reported sleep disturbances 2. Habitual smoking (\> 1 occasion/month) 3. Any kind of injury/incapability that is a contra-indication to perform high intensity interval training 4. Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using an adequate, highly effective contraceptive. A woman is considered of childbearing potential (WOCBP), i.e. fertile, following menarche and until becoming post menopausal unless permanently sterile. Permanent sterilisation methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy. 5. Participation in another interventional Trial with an investigational medicinal product (IMP) or device 6. Use of CBD related products 3 months prior to the start of the experimental trial (including CBD oil, cannabis or other substances containing cannabinoids) 7. Intake of any medication or nutritional supplement that influences sleep quality 3 months prior to the start of the experimental trial 8. Shift workers or extreme morning and evening chronotypes (scores between 16-30 or 70-86 on the Morningness-Eveningness Questionnaire (MEQ))
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Bakala Athletic Performance Facility
RECRUITINGLeuven, Vlaams-Brabant, 3001, Belgium
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