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Could CBD and CBN ease your jaw pain and headaches?

NCT ID NCT05961501

Symptom relief Sponsor: Wroclaw Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a drink containing CBD and CBN can reduce facial pain and headaches caused by muscle tension. 42 adults with pain lasting over 3 months will be randomly assigned to receive either the CBD/CBN drink or a placebo. Researchers will measure pain and muscle activity over 60 days to see if the treatment helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cannabidiol (CBD) and cannabinol (CBN) oral solution
What this could lead to
If it works, this could point toward a new, natural option for managing chronic facial pain and tension headaches.
What could go wrong
This is a small, early-phase trial with only 42 people, so results may not apply to everyone. The study is also placebo-controlled, so any benefit might be due to the placebo effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 42 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * facial pain and headache of muscular origin for more than 3 months Exclusion Criteria: * patients under 18 years of age, * patients who are allergic to any ingredient of the preparation, * pregnant or breast-feeding women, * patients taking preparations that contain similar ingredients and/or have similar effects, * obese patients, * patients with active cancer, * patients with severe systemic diseases, including genetic and neurological diseases, * patients with severe mental illnesses, * patients who are taking or in the last 12 months have taken antidepressants and/or myorelaxants and/or other drugs that affect neuromuscular activity, * patients addicted to alcohol or drugs.

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Conditions

The condition(s) this trial relates to.

Facial Pain Headache headache disorder Myalgia myofascial pain syndrome Tension-Type Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Headache Headache, tension Headaches muscular Muscle pain Myalgia Orofacial pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Wroclaw Medical University

    Wroclaw, 50-425, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.