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Carpal tunnel showdown: shots or knife?
NCT ID NCT05306548
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at two treatment plans for carpal tunnel syndrome, which causes hand numbness and pain. One plan starts with up to two steroid injections, then offers surgery if needed. The other plan goes straight to surgery. About 258 adults with mild to moderate symptoms will be followed for two years to see which approach works better.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 258 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2022
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult (≥18 years of age) 2. Patient history indicating CTS 3. Neurophysiological examination performed within 6 months 4. Diagnosis of CTS based on: 1. Classic/probable or possible symptoms, and neurophysiological findings consistent with CTS Or, in case of normal neurophysiological findings: 2. Classic/probable symptoms and positive physical exam findings and/or nighttime symptoms 5. Mild to moderate symptoms (intermittent, interfering with everyday life, and/or disturb sleep) Exclusion Criteria: 1. Previous CTS surgery or corticosteroid injection in the carpal tunnel in the relevant hand 2. Diagnosis of severe CTS, based on history and examination indicating severe CTS with constant symptoms including pain, loss of sensibility, dexterity or reduced temperature sensation, weakness of thumb abduction and opposition, or atrophy of thenar musculature. Disappearance of pain may indicate permanent sensory loss. 3. History suggesting underlying causes of CTS e.g. inflammatory wrist arthritis and/or flexor tenosynovitis 4. Previous significant trauma or fracture, deformity or tumor in the wrist or hand in the relevant hand 5. Presence of conditions affecting a normal nerve function e.g. cervical disc herniation, polyneuropathy or previous nerve injury 6. Major co-morbidities, such as severe malignancies, severe or uncontrolled infections, uncontrollable hypertension, severe cardiovascular disease (NYHA class III or IV) and/or severe respiratory diseases, severe renal failure, active ulcus ventriculi, leukopenia and/or thrombocytopenia 7. Severe psychiatric or mental disorders 8. Local infection or wound in the affected hand/wrist 9. Any other medical condition that according to the treating physician and/or local guidelines makes adherence to treatment protocol impossible 10. Inadequate birth control1, pregnancy2, and/or breastfeeding (current at screening or planned within the duration of the study) 11. Known hypersensitivity to Triamcinolone Hexacetonide (Lederspan) or any of the excipients (sorbitol, polysorbate or benzyl alcohol) 12. Concomitant therapy with CYP3A-inhibitors or digitalis glycosides 13. Patients vaccinated or immunized with live virus vaccines within 2 weeks of treatment 14. Alcohol or other substance abuse 15. Language barriers 16. Other factors which make adherence to study protocol impossible
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Akershus University Hospital
Lørenskog, Akershus, 1461, Norway
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Department of Orthopedic Surgery, Martina Hansens Hospital
Sandvika, Norway
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Department of Rheumatology, Diakonhjemmet Hospital
Oslo, 0319, Norway
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Department of Rheumatology, Martina Hansens Hospital
Sandvika, Norway
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Department of Surgery and Anesthesiology, Diakonhjemmet Hospital
Oslo, Norge, 1450, Norway
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Does mixing numbing agent into steroid shots ease hand pain?
- Blood protein may reveal how severe carpal tunnel syndrome is
- A carpal tunnel clue to a silent heart threat?
- Taping technique may offer Drug-Free relief for wrist pain
- One size Doesn't fit all: could pain 'Phenotypes' unlock better carpal tunnel care?
- Ultrasound may reveal hidden clues in carpal tunnel syndrome