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Carpal tunnel showdown: shots or knife?

NCT ID NCT05306548

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two treatment plans for carpal tunnel syndrome, which causes hand numbness and pain. One plan starts with up to two steroid injections, then offers surgery if needed. The other plan goes straight to surgery. About 258 adults with mild to moderate symptoms will be followed for two years to see which approach works better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 258 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2022

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult (≥18 years of age) 2. Patient history indicating CTS 3. Neurophysiological examination performed within 6 months 4. Diagnosis of CTS based on: 1. Classic/probable or possible symptoms, and neurophysiological findings consistent with CTS Or, in case of normal neurophysiological findings: 2. Classic/probable symptoms and positive physical exam findings and/or nighttime symptoms 5. Mild to moderate symptoms (intermittent, interfering with everyday life, and/or disturb sleep) Exclusion Criteria: 1. Previous CTS surgery or corticosteroid injection in the carpal tunnel in the relevant hand 2. Diagnosis of severe CTS, based on history and examination indicating severe CTS with constant symptoms including pain, loss of sensibility, dexterity or reduced temperature sensation, weakness of thumb abduction and opposition, or atrophy of thenar musculature. Disappearance of pain may indicate permanent sensory loss. 3. History suggesting underlying causes of CTS e.g. inflammatory wrist arthritis and/or flexor tenosynovitis 4. Previous significant trauma or fracture, deformity or tumor in the wrist or hand in the relevant hand 5. Presence of conditions affecting a normal nerve function e.g. cervical disc herniation, polyneuropathy or previous nerve injury 6. Major co-morbidities, such as severe malignancies, severe or uncontrolled infections, uncontrollable hypertension, severe cardiovascular disease (NYHA class III or IV) and/or severe respiratory diseases, severe renal failure, active ulcus ventriculi, leukopenia and/or thrombocytopenia 7. Severe psychiatric or mental disorders 8. Local infection or wound in the affected hand/wrist 9. Any other medical condition that according to the treating physician and/or local guidelines makes adherence to treatment protocol impossible 10. Inadequate birth control1, pregnancy2, and/or breastfeeding (current at screening or planned within the duration of the study) 11. Known hypersensitivity to Triamcinolone Hexacetonide (Lederspan) or any of the excipients (sorbitol, polysorbate or benzyl alcohol) 12. Concomitant therapy with CYP3A-inhibitors or digitalis glycosides 13. Patients vaccinated or immunized with live virus vaccines within 2 weeks of treatment 14. Alcohol or other substance abuse 15. Language barriers 16. Other factors which make adherence to study protocol impossible

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Akershus University Hospital

    Lørenskog, Akershus, 1461, Norway

  • Department of Orthopedic Surgery, Martina Hansens Hospital

    Sandvika, Norway

  • Department of Rheumatology, Diakonhjemmet Hospital

    Oslo, 0319, Norway

  • Department of Rheumatology, Martina Hansens Hospital

    Sandvika, Norway

  • Department of Surgery and Anesthesiology, Diakonhjemmet Hospital

    Oslo, Norge, 1450, Norway

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