Which radiation is safer for the heart? new study compares proton and photon therapy in breast cancer patients.
NCT ID NCT04361240
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 172 breast cancer patients to see how proton radiation compares to standard photon radiation in terms of heart health. Researchers measured heart function and blood markers before, during, and up to one year after treatment. The goal was to understand which type of radiation might be safer for the heart.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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172 people
The number who actually took part.
- Started
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Aug 2020
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients eligible for and enrolling on the RadComp trial at participating RadComp sites will be approached for the companion cohort.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Consented to RadComp * Willing and able to provide written consent Exclusion Criteria: * Knowledge of randomization on RadComp prior to enrollment on companion study * Non-diagnostic echocardiography windows as assessed on local read.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Abramson Cancer Center at University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Johns Hopkins
Baltimore, Maryland, 21287, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Northwestern Medicine
Warrenville, Illinois, 60555, United States
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University of Alabama
Birmingham, Alabama, 35233, United States
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University of Washington
Seattle, Washington, 98195, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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