New combo therapy aims to outsmart tough hodgkin lymphoma

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Arm 1: Relapse After Prior CD 30 CAR-T Therapy * Written informed consent obtained to participate in the study and HIPAA authorization for release of personal health information. * Age ≥18 years at the time of consent. * Subject is planned to start on standard of care anti-PD-1 therapy per community standards of medical care by their treating oncologist. * Subject has a diagnosis of relapsed/refractory classical Hodgkin lymphoma after at least three lines of prior therapy with clinical progression after either ATLCAR.CD30 and/or ATLCAR.CD30.CCR4. The CAR-T cell product may be either the UNC, Baylor or Tessa product. * Subjects with prior allogeneic stem cell transplant will be eligible but will be counseled during consent regarding possible increased risk of graft versus host disease with anti-PD-1 therapy after allogeneic stem cell transplant. * Subjects must have previously been treated with anti-PD-1 therapy (any anti-PD-1 therapy either standard of care or investigational) prior to receiving autologous CAR-T-cell therapy. * Subject is willing to provide blood samples that are clinically necessary during anti-PD-1 therapy administered per community standards of medical care. Inclusion Criteria for Arm 2: Relapse with no Prior CD 30 CAR-T Therapy * Written informed consent obtained to participate in the study and HIPAA authorization for release of personal health information. * Age ≥18 years at the time of consent. * Subject is planned to start on standard of care anti-PD-1 therapy per community standards of medical care by their treating oncologist. * Subject has a diagnosis of classical Hodgkin lymphoma. * Subjects with prior allogeneic stem cell transplant will be eligible but will be counseled during consent regarding possible increased risk of graft versus host disease with anti-PD-1 therapy after allogeneic stem cell transplant. * Subject is willing to provide blood samples that are clinically necessary during anti-PD-1 therapy administered per community standards of medical care. * Subject is willing and able to comply with study procedures based on the judgment of the investigator or protocol designee. * Subject is willing to consent to study-required blood draws. Exclusion Criteria for Arm 1: Relapse After Prior CD 30 CAR-T Therapy * Subject has received anti-CD30 CAR-T therapy within the previous 6 weeks. * Subject has known active infection with HIV, HTLV, HBV, HCV or any active, uncontrolled infection or sepsis. * Subject has received chemotherapy or anti-PD-1 therapy following CD30 CAR-T cell product administration. * Subject has a known additional malignancy that is active and/or progressive requiring treatment; exceptions include basal cell or squamous cell skin cancer, in situ cervical or bladder cancer, or other cancer for which the subject has been disease-free for at least five years. * Subject is currently using systemic corticosteroids at doses ≥10 mg prednisone daily or its equivalent, or other immunosuppressive medications. Exclusion Criteria for Arm 2: Relapse with no Prior CD 30 CAR-T Therapy * Subject has received anti-CD30 CAR-T therapy * Subject is currently using systemic corticosteroids at doses ≥10 mg prednisone daily or its equivalent, or other immunosuppressive medications.