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Faster braces, less bone loss? new study tests PRP and decortication

NCT ID NCT06500559

Knowledge-focused Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at 60 people aged 16-22 who needed braces and had a premolar removed. Researchers compared two methods—PRP injections and a minor surgical procedure called decortication—to see if they could speed up tooth movement and reduce bone defects like dehiscence and fenestration. The goal is to make orthodontic treatment faster and safer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich plasma (PRP) injection and alveolar decortication
What this could lead to
If successful, this could point toward safer, faster orthodontic treatments with fewer complications like gum recession or bone loss.
What could go wrong
This is a small, completed study with only 60 participants, so results may not apply to everyone. The methods are still experimental and need more research.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

May 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 22 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age of the patients ranged from 16: 22 years old. 2. Malocclusion that requires extraction of the maxillary first premolar and canine retraction (e.g. class I bimaxillary dentoalveolar protrusion and class II div 1 malocclusion). 3. Maximum anchorage needed for the maxillary arch as a part of the orthodontic treatment plan. 4. Good oral hygiene and periodontal condition. Exclusion Criteria: 1. Medically compromised patients. 2. Severe crowding in the maxillary arch. 3. Chronic intake of NSAIDs or any medication that interfere with OTM. 4. Previous orthodontic treatment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dehiscence Fenestration

Contacts and locations

Locations

  • Tanta University

    Tanta, Tanta, 6624033, Egypt

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