Could your own blood heal your jaw after a tooth extraction?
NCT ID NCT07585123
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a substance made from a patient's own blood, called platelet-rich fibrin (L-PRF), can prevent a serious condition called jawbone death after tooth extraction. The trial will include 40 people at high risk due to past radiation or certain medications. Half will get L-PRF in the extraction socket, and half will get standard care, with healing checked over a year.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Platelet-rich fibrin (L-PRF) made from the patient's own blood
- What this could lead to
- If it works, this could point toward a simple, low-cost way to prevent severe jawbone damage in people who have had radiation or take certain bone medications.
- What could go wrong
- This is a very small, early feasibility trial with only 40 people. It may not show a clear benefit, and the results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: -General Inclusion Criteria (Applies to All Participants) Age ≥18 years Requiring extraction of one or more teeth with hopeless prognosis Capacity to provide informed consent Ability and willingness to attend all scheduled follow-up visits over 12 months -Post-Radiotherapy Group - Specific Inclusion Previous radiotherapy to the head and neck region Documented radiation dose ≥50 Gy Radiotherapy records (dose, field, date) must be available -Antiresorptive Group - Specific Inclusion Current or prior use of antiresorptive agents (e.g. bisphosphonates or denosumab) Medication history must be available in medical records Exclusion Criteria: * General Exclusion Criteria (Applies to All Participants) Inability to maintain adequate oral hygiene due to motor disability Uncontrolled systemic illness (e.g. uncontrolled diabetes) Use of anticoagulants, immunosuppressants, or medications known to impair healing Requirement for surgical (complex) extractions Enrolment in another clinical trial Known allergy to anaesthetic agents, L-PRF components, or antibiotics used in perioperative protocol Anticipated non-compliance with follow-up -Post-Radiotherapy Group - Specific Exclusion Previous or current antiresorptive therapy History of re-irradiation or radiation dose \<50 Gy -Antiresorptive Group - Specific Exclusion History of head and neck radiotherapy Neoplastic involvement of the jaws Active untreated oral infection or pathology at time of planned extraction
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Morriston Hospital
Swansea, SA6 6NL, United Kingdom
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