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Could your mouthwash fight gonorrhea? new study investigates

NCT ID NCT04966507

Prevention Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tested whether using an antibacterial mouthwash every day could lower the chance of getting gonorrhea in the throat. Researchers recruited 89 HIV-positive and HIV-negative men at high risk. Participants gargled with either Listerine or a placebo mouthwash daily. The study looked at how well people stuck with the routine and whether the mouthwash reduced infections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Listerine Antiseptic Mouthwash (active ingredients: eucalyptol, menthol, methyl salicylate, thymol)
What this could lead to
If it works, daily mouthwash could become a simple, low-cost way to help prevent throat gonorrhea infections.
What could go wrong
This is a small, early-phase trial with only 89 participants. The mouthwash may not reduce infections enough to be meaningful, and results may not apply to the general population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

89 people

The number who actually took part.

Started

Feb 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

This study will only include participants recruited as part an NIH/NIDA funded study (U01 DA036267 PIs Gorbach and Shoptaw) - the mSTUDY. By design, half of the participants are HIV-positive and half are HIV-negative and other inclusion criteria for the mSTUDY are as follows: 1. At least 18 but not older than 45 years of age on day of consent 2. Identified biologically male at birth 3. Willing to return for follow-up study visits every 6 months as long as the study is ongoing and be available to return for all study visits, barring unforeseen circumstances 4. Willing and able to provide written informed consent to take part in the study 5. Willing and able to provide adequate information for locator purposes 6. STI testing at each study visit (with reporting and treatment referral when indicated) 7. Understands and agrees to local STI reporting requirements 8. If HIV-negative at screening, report unprotected anal intercourse with a male in the past 6 months Additional inclusion criteria specific to this study are: 9. Currently enrolled in mSTUDY 10. mSTUDY participants who have turned 45 since enrollment in mSTUDY continue to be eligible for inclusion in this study. 11. Previously diagnosed with pharyngeal gonorrhea (while an mSTUDY participant) Participants will be excluded from the study if: 1. Mouthwash use is contraindicated, for example because of allergies or those who may need to avoid the high alcohol content of mouthwash such as recovery alcoholics maintaining their sobriety 2. They are unwilling to stop use of their current mouthwash during the 24-week study period

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Conditions

The condition(s) this trial relates to.

gonorrhea prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gonorrhea

Contacts and locations

Locations

  • Los Angeles LGBT Center

    Los Angeles, California, 90028, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.