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Can a simple genetic test get more people on heart-saving statins?

NCT ID NCT07260552

Prevention Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether giving patients and their doctors a polygenic risk score — a genetic test that estimates future risk of coronary heart disease — helps more people start taking statins to prevent heart problems. Researchers will enroll 200 adults aged 40-69 without prior heart disease or statin use from rural and urban clinics. Half will get the genetic risk score along with standard risk assessment; the other half will get standard assessment alone. The main goal is to see if the genetic information leads to more statin prescriptions and lower cholesterol.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
polygenic risk score (genetic screening tool)
What this could lead to
If successful, this could show that using a genetic risk test in primary care helps more people start preventive medication and lower their heart disease risk.
What could go wrong
This is a small, early-stage study focused on feasibility and uptake, not on actual heart attacks or deaths. The genetic test may not change behavior or outcomes in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2027

An estimate. Start dates often move.

Expected to finish

Jan 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults who receive their primary care in Milwaukee and Shawano Counties in the state of Wisconsin.

Ages

40 to 69 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 40-69 years of age * No prior history of coronary heart disease * No prior use of statin medication * Has primary care provider Exclusion Criteria: * Prior history of coronary heart disease * current use of statin medication

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Coronary Disease Genetic Risk Score

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary heart disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.