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Could a simple painkiller injection ease Post-Surgery pain?

NCT ID NCT07429448

Symptom relief Sponsor: Sardar Umer Rehman Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether placing the numbing drug bupivacaine into the abdomen during open appendix surgery can reduce pain afterward. Sixty adults having open appendectomy will receive either bupivacaine or a saltwater placebo. Researchers will measure pain levels and how often extra painkillers are needed over the first 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine
What this could lead to
If it works, this could offer a simple way to reduce pain after open appendix surgery, possibly lowering the need for strong painkillers.
What could go wrong
This is a very early phase 1 trial with only 60 participants, so results may not be conclusive. The effect may be small or not better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients presenting to the emergency department undergoing open appendectomy. Exclusion Criteria: * Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness/ fever) and USG findings (presence of abscess, fluid collection, or free air). * Uncontrolled medical disease (DM: BSL \>200mg/dl, HTN: BP \>140/90) * History of chronic kidney or liver disease/ psychiatric illness/ Active peptic ulcer disease (as determined on history and medical records) * Alcoholics * History of chronic pain or patients on analgesic medications * Pregnant females * History of allergy to bupivacaine/ ketorolac as determined on history * Children, Adolescents and patients with mental illness.

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Conditions

The condition(s) this trial relates to.

agnosia appendicitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appendectomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Services Institute of Medical Sciences/ Services Hospital Lahore

    RECRUITING

    Lahore, Punjab Province, 54000, Pakistan

More trials for these conditions

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