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Study reveals hidden breathing issues in severe MS patients

NCT ID NCT03339817

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at breathing problems in 70 people with severe multiple sclerosis (MS). Participants had sleep and lung tests to check for breathing muscle weakness. The goal was to better understand how MS affects breathing, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand and detect breathing problems in people with severe multiple sclerosis.
What could go wrong
This is an observational study with only 70 participants, so findings may not apply to everyone. It does not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Jan 2018

Finished

Nov 2020

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis criteria of multiple sclerosis (MS) fulfilling revised McDonald criteria (2010) * EDSS score from 6.5 * no relapse during the 3 last months * Informed consent prior to any study procedure Exclusion Criteria: * Any severe Chronic Obstructive Pulmonary Disease (III or IV) * Pregnancy or woman with childbearing potential * contraindication to MRI

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Conditions

The condition(s) this trial relates to.

multiple sclerosis Respiration Disorders respiratory system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis Respiration disorders

Contacts and locations

Locations

  • Département de Neurologie-Groupe Hospitalier Pitié-Salpêtrière

    Paris, Paris, 75013, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.