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Brain games and movement may boost MS memory

NCT ID NCT03737825

Symptom relief Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested two different computerized brain training programs that also involve light physical activity, like reaching or stepping, in people with multiple sclerosis who have memory or attention problems. The goal was to see if these programs could improve thinking speed and focus. Only 2 participants were enrolled, making this a very early, small test.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Computerized brain training games with light physical activity
What this could lead to
If it works, this could point toward a simple, non-drug way to help people with MS think more clearly and remember better.
What could go wrong
This is a very small pilot study (only 2 participants enrolled) with no control group, so results may not be reliable or apply to others. The brain training may not improve thinking skills at all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

2 people

The number who actually took part.

Started

Apr 2019

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 60 years * Presence of subjective cognitive complain from patient * Objective general cognitive impairment: paper-and-pencil Symbol Digit Modalities Test (SDMT) z-score \< -0.5 at screening Exclusion Criteria: * Falls in the past 12 weeks as evaluated in the enrollment interview \[Hopkins Falls Grading Scale (Grade \>1)\] * Strong risk of falling, assessed using the miniBEST (score\< 16) * Psychiatric co-morbidity or anti-depressive or anxiolytic medication that has been changed over the 6 months preceding consideration for study enrollment * Colorblindness * Presence of clinically and/or radiologically confirmed relapses or disease progression in the past 12 weeks. * Visual, mental, motor or brainstem Functional Systems Score (FSS) on the Expanded Disability Status Scale (EDSS) superior to 2.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive decline Multiple sclerosis

Contacts and locations

Locations

  • Lausanne University Hospital (CHUV)

    Lausanne, 1005, Switzerland

  • Weill Institute for Neurosciences, University of California, San Francisco

    San Francisco, California, 94158, United States

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