Could a quick brain zap ease Long-Term nerve pain?
NCT ID NCT07650526
First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 8 times
Summary
This study tests two non-invasive brain stimulation techniques—standard rTMS and a faster version called aiTBS—against a sham (fake) treatment in 30 adults with chronic neuropathic pain lasting at least 6 months. Participants receive both active and sham treatments in a random order, with a washout period in between. The goal is to see if these methods reduce pain and to find predictors of who might benefit most.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial magnetic stimulation (TMS) - a non-invasive device that uses magnetic pulses to stimulate the brain
- What this could lead to
- If successful, this could offer a faster, more convenient non-drug option for managing chronic neuropathic pain.
- What could go wrong
- This is a small early-stage trial with only 30 participants. The effects may be modest or not last long, and not everyone may respond.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age over 18 years and less than 80 years 2. Average pain intensity ≥ 4/10 on the numerical scale of the Brief Pain Inventory at screening and randomization 3. Pain present for at least 4 days per week 4. Persistent pain for at least 6 months 5. Stable pharmacological treatment for pain for at least 1 month prior to the study. 6. Peripheral or central neuropathic pain (postherpetic neuralgia, painful neuropathies, nerve lesions, radiculopathy, trigeminal neuralgia, stabilized multiple sclerosis, spinal cord lesion or stroke) fulfilling criteria for probable or definite neuropathic pain; and scoring ≥ 4 out of 10 on the DN4 questionnaire 7. Informed consent 8. Patients who can be followed for the whole duration of the study 9. Patients affiliated to social security in France Exclusion Criteria: 1. Ongoing litigation 2. Contraindication to rTMS : * implanted electronic devices and/or conductive objects near the coil: patients with an active implanted device activated or controlled by physiological signals (e.g. pacemakers, implanted cardioverter defibrillators \[ICD\], vagus nerve stimulators \[VNS\] and portable cardioverter defibrillators \[WCD\], ocular implants, deep 16 brain stimulation, drug chambers/pumps, intracardiac leads) even if the device has been removed. * Non-removable metal objects near the coil: Patients with a conductive implant, ferromagnetic or made of any other metal sensitive to magnetic fields, in the head or at a distance of less than 30 cm from the coil (e.g. cochlear implant, implanted electrodes/pacemakers, aneurysm clips or coils, stents and bullet fragments). 3. Current drug or psychoactive substance abuse (DSM V) 4. Pregnancy or lactation 5. Epilepsia or past epilepsia 6. Progressive unsable pathology (eg cancer) 7. Current psychosis according to DSM V criteria 8. Presence of other pain more severe than that justifying inclusion 9. Lack of correct completion of pain self-assessment diaries between inclusion and randomisation (at least 4 weekly pain scores over 7 days), 10. Subject unable to understand informed consent, under guardianship or curatorship 11. Patients participating in another research protocol within 30 days prior to inclusion. 12. Patient who has already received a treatment with rTMS
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hopital Ambroise-Paré INSERM U987, 9 Av. Charles de Gaulle
RECRUITINGBoulogne-Billancourt, Île-de-France Region, 92100, France
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