CHRONIC NEUROPATHIC PAIN

This early-stage study is testing a single-dose gene therapy for people with severe, treatment-resistant nerve pain from small fiber neuropathy. The therapy, called ST-503, is injected into the spinal fluid and aims to block pain signals at their source. Researchers will first ch…

This study is testing whether a small implanted device that sends electrical pulses near spinal nerves can reduce chronic nerve pain. It involves 17 adults with long-term pain that hasn't improved with standard treatments. Researchers will track pain levels, daily function, and q…

This study tests whether magnetic stimulation of the brain can reduce chronic nerve pain in cancer patients. 60 participants with pain that hasn't responded well to medications will receive either real or fake (placebo) brain stimulation sessions. Researchers will compare pain re…

This study is testing if a nerve stimulation device, added to standard medical care, works better than standard care alone for reducing chronic nerve pain in the lower back, pelvis, or legs. About 150 adults with long-term pain from a specific nerve injury will be randomly assign…

This small pilot study is testing whether MDMA (commonly known as ecstasy), combined with psychotherapy, can help people with severe, treatment-resistant nerve pain. Forty adults with long-term, debilitating pain will receive either MDMA or an active placebo during a guided thera…