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Magnetic pulses to the brain may ease neck dystonia symptoms

NCT ID NCT07681284

Symptom relief Sponsor: Fondazione Policlinico Universitario Campus Bio-Medico Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Sep 18, 2026 · Updated 2 times

Summary

This study investigates whether a type of noninvasive brain stimulation called continuous theta-burst stimulation (cTBS) can reduce symptoms of cervical dystonia, a condition that causes involuntary muscle contractions in the neck and head. Participants receive either real or sham cTBS over eight days, with symptom changes measured using clinical scales and motion sensors. The trial aims to see if this safe, drug-free approach can improve movement, pain, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
continuous theta-burst stimulation (cTBS) using a magnetic coil
What this could lead to
If effective, this could offer a noninvasive, drug-free option to ease muscle spasms and pain in cervical dystonia.
What could go wrong
This is a small, early-stage trial with 26 participants, so results may not apply widely. The treatment is experimental and may not work better than a sham procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 26 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Aged between 18 and 85 years * Diagnosis of idiopathic cervical dystonia made by an expert physician * Last botulinum toxin injection administered at least two months before the start of participation in the study (Albanese, Abbruzzese et al. 2015) Exclusion Criteria * Head or neck trauma occurring less than 12 months before the onset of dystonia * Acquired dystonia (e.g., drug-induced, brain lesions or trauma) * History of major psychiatric disorders (e.g., bipolar disorder, schizophrenia, obsessive-compulsive disorder) * History of neurological diseases other than CD (e.g., epilepsy, Parkinson's disease) * Other contraindications for TMS or brain MRI (e.g., metal in the head) * Pregnant or breastfeeding women * History of substance abuse or dependence

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Conditions

The condition(s) this trial relates to.

cervical dystonia Torticollis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical dystonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Università Campus Bio-Medico

    RECRUITING

    Roma, Roma, 00128, Italy

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