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Scientists test whether different electrical currents change how the brain senses pain

NCT ID NCT07831525

NEW Knowledge-focused Sponsor: Hospital de Clinicas de Porto Alegre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers compare three non-invasive brain stimulation techniques, direct current, alternating current, and random noise current, against a sham session and a rest session in 14 healthy men aged 18 to 45. Each participant receives all conditions in a randomized, double-blind, crossover design. The team measures brain wave activity, motor cortex excitability, blood flow changes in the motor cortex, and pain thresholds after a cold-water pain stimulus. The goal is to understand how each current affects the sensorimotor pathway.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial electrical brain stimulation, including direct current, alternating current, and random noise current
What this could lead to
If the currents change brain and nerve activity in useful ways, this could inform future neuromodulation strategies for conditions where the sensorimotor pathway is disrupted.
What could go wrong
This is a very small, single-session study in healthy young men, so any effects may be temporary, may not translate to patients, and may not apply to women or other age groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 14 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy male subjects aged 18-45 years, with at least a high school diploma, and not engaged in night-shift work. Exclusion Criteria: * Contraindications to transcranial stimulation include implanted medical devices in the brain, cardiac pacemakers, and cochlear implants. * Current use of psychotropic medications. * History of alcohol or substance abuse within the past 6 months. * Neurological disorders, history of traumatic brain injury, or prior neurosurgery. * Beck Depression Inventory-II (BDI-II) score \>13. * Self-Reporting Questionnaire (SRQ) score \>7.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Health adult subjects

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, Brazil

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