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Beetroot boost: does more nitrate mean more endurance?

NCT ID NCT07735455

Knowledge-focused Sponsor: Universidad Autonoma de Madrid Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This pilot study explores whether a single dose of dietary nitrate, a natural compound found in beetroot and leafy greens, can improve running endurance and reduce muscle fatigue. Recreationally active men will take either a placebo or one of three nitrate doses before a treadmill test to exhaustion. The goal is to see if higher doses lead to greater benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dietary nitrate (from beetroot or leafy greens)
What this could lead to
If it works, this could point toward an optimal dose of dietary nitrate for boosting endurance in recreational runners.
What could go wrong
This is a very small pilot study with only 9 participants, so results may not apply to others. Higher doses might cause digestive upset or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

9 people

The number who actually took part.

Started

Oct 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male adults aged 18 to 40 years. * Recreationally trained, performing endurance or combined endurance/resistance exercise at least 3 times per week for the previous 6 months. * Maximal oxygen uptake (VO₂max) consistent with recreational training status. * Able to perform maximal treadmill running exercise. * Willing and able to comply with all study procedures. * Provided written informed consent before participation Exclusion Criteria: * Current smoking or use of nicotine products. * History of cardiovascular, pulmonary, metabolic, neurological, or musculoskeletal disorders that could affect exercise performance or participant safety. * Current use of medications or dietary supplements known to influence nitric oxide metabolism or exercise performance (e.g., nitrate supplements, phosphodiesterase-5 inhibitors, antibacterial mouthwash). * Allergy or intolerance to beetroot or any component of the study supplements. * Following a vegetarian or vegan diet, or habitually consuming a high-nitrate diet. * Consumption of alcohol, caffeine, or strenuous physical exercise within the period restricted by the study protocol before each experimental visit. * Failure to comply with pre-test dietary or behavioral instructions. Participation in another clinical trial within the previous 30 days. * Any condition that, in the opinion of the investigators, could interfere with study participation or interpretation of the results.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Health adult subjects

Contacts and locations

Locations

  • Universidad Autónoma de Madrid

    Madrid, Madrid, 28049, Spain

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