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A simple bedside test may predict brain damage after cardiac arrest

NCT ID NCT06776302

Knowledge-focused Sponsor: University Medical Centre Maribor Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial investigates whether two simple, non-invasive tests can detect changes in brain oxygen levels in unconscious patients who have survived a cardiac arrest. The tests involve a controlled infusion of a blood-pressure-raising drug and a passive leg raise to increase blood flow to the brain. Researchers aim to see if these oxygen changes match other established methods for assessing neurological damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
norepinephrine infusion and passive leg raise
What this could lead to
If successful, this approach could offer a simple, bedside way to assess brain damage in unconscious patients after cardiac arrest.
What could go wrong
This is a very small, early-stage study with only 20 participants. The tests are not used to guide treatment, and results may not translate to better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

May 2024

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age over 18 years * Out-of-hospital cardiac arrest * Unconsciousness after return of spontaneous circulation (8 points or less on the Glasgow Coma Scale) Exclusion Criteria: * Intracranial hemorrhage (clinically suspected or proven by CT scan) * Hypothermia (body temperature less than 32 degrees Celsius) * Pregnancy * Uncontrollable bleeding * Uncontrollable blood pressure fluctuations * Patient defined as palliative or terminal * Cardiac arrest secondary to drowning, hypothermia, or trauma

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Conditions

The condition(s) this trial relates to.

cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest (CA)

Contacts and locations

Locations

  • University clinical center Maribor

    Maribor, 2000, Slovenia

More trials for these conditions

Other studies related to the condition(s) this trial covers.