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Brain scans reveal secrets of bladder leaks in women over 60

NCT ID NCT04227184

Knowledge-focused Sponsor: Becky Clarkson Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how the brain works in women aged 60 and older who have sudden, strong urges to urinate (urgency urinary incontinence). Participants took a medication called trospium or a placebo, and had brain scans (MRI) to see if changes in brain activity relate to fewer leaks. The goal was to learn more about the brain's role in bladder control, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

168 people

The number who actually took part.

Started

Feb 2020

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 60+ years old 2. Has UUI or urge-predominant mixed incontinence at least 5 times/ week for \> 3 months despite treatment for reversible causes Exclusion Criteria: 1. conditions/medications contraindicating trospium 2. If currently taking anticholinergic medications (participant must refrain from anticholinergic medications for 4 weeks prior enrollment in order to be eligible) 3. Impaired mobility or cognition sufficient to preclude following study procedures; MoCA test score \<24/30; a clinically-apparent neurological condition 4. Prolapse beyond the hymen 5. Interstitial cystitis 6. Spinal cord injury 7. History of pelvic radiation or advanced uterine/bladder cancer 8. Urethral obstruction (uroflow); PVR \>200 ml 9. Medical instability 10. Prior UUI treatment with onabotulinum toxin or neuromodulation 11. Drug interaction or expected medication change during the study 12. Conditions requiring IV antibacterial prophylaxis 13. New incontinence treatment \< 3 months prior to enrollment 14. Fecal incontinence, and symptomatic colitis/IBS 15. Contraindications to MRI.

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Conditions

The condition(s) this trial relates to.

overactive bladder Urinary Incontinence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Urgency urinary incontinence

Contacts and locations

Locations

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.