New brain scan tracer could unlock secrets of stress and anxiety
NCT ID NCT03520543
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 38 times
Summary
This completed Phase 1 study tested a radioactive tracer called [11C]Yohimbine in 16 healthy men to see how it binds to alpha2-adrenergic receptors in the brain using PET scans. The goal was to model the tracer's movement and measure its binding, as well as test how a drug called clonidine blocks its uptake. This research aims to improve brain imaging techniques for studying conditions like anxiety and depression.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Service de Neurologie C - Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, GHE
Bron, 69500, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
[11C]Yohimbine (a radioactive tracer for PET scans)
What this could lead to
If successful, this could improve how doctors use PET scans to study brain receptors, potentially aiding research into conditions like depression or anxiety.
What could go wrong
This is a very early, small study in only 16 healthy men, so results may not apply to patients or lead to any direct treatment. The tracer is radioactive, though doses are low.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.