Scientists scan brains of binge drinkers to uncover why they crave alcohol
NCT ID NCT07220148
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how the brain, stress hormone cortisol, and immune factor interleukin-6 change when people who binge drink see pictures of alcohol. Researchers will use MRI scans and blood tests, and participants will also taste beer in the lab. The goal is to better understand what drives drinking behavior, which could help develop new treatments for Alcohol Use Disorders.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could point toward new treatments for Alcohol Use Disorders by identifying key biological targets.
- What could go wrong
- This is an observational study, not a treatment trial. It is early-stage and may not directly lead to therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 234 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 25 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: In this study, researchers will recruit 234 individuals who report binge use of alcohol or who consume alcohol moderately with no episodes of binge drinking. All participants will be recruited from the community primarily through advertisements in local newspapers, online venues like craigslist, flyers, and list-serve emails, as well as through radio and other media advertisements. Inclusion Criteria All Participants: * Male and Females between the ages of 21-25 * able to read and write in English and complete study evaluations * able to provide negative breathalyzer and negative toxicology screenings for substances at all study appointments * able to provide written and verbal consent. * Must be a beer drinker (not exclusively), to ensure subjects are not averse to the taste of beverages presented in the ATT * BMI of 18-35 Binge Drinkers: • At least twice per month binge drinking and weekly alcohol use of at least 8 standard drinks/week females or 15 or more drinks for males for the past year, with binge drinking defined as drinking enough alcohol that brings blood alcohol concentration to 0.08 percent or higher in about 2 hours, which is typically equivalent to consuming 5 or more drinks for males, or 4 or more drinks for females. Social Drinkers: • at least weekly alcohol use for the past 6 months not to exceed 7 standard drinks/wk for women and 14 standard drinks/week for males, with no episodes of binge drinking in the past year Exclusion Criteria: All Participants: * Any psychotic disorder or current psychiatric symptoms requiring specific attention, including active symptoms of psychosis or suicidal/homicidal ideation * meets criteria for current or past moderate or severe substance use disorder * women who are pregnant or lactating * inability to give informed consent * any contraindications for MRI (e.g., medical devices in the body, claustrophobia, etc) * current PTSD or acute stress disorder * other illicit drug use as determined by a urine drug screen
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Auburn University MRI Center
Auburn, Alabama, 36832, United States
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