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Scientists probe why POTS patients feel foggy

NCT ID NCT04137757

Knowledge-focused Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at why people with Postural Tachycardia Syndrome (POTS) often have trouble thinking clearly, known as 'brain fog.' Researchers will compare brain scans of 21 POTS patients and healthy volunteers while they do mental tasks, both sitting and under simulated standing stress. The goal is to see if brain regions work harder in POTS patients, especially when upright.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help explain the cause of brain fog in POTS, pointing toward future treatments or management strategies.
What could go wrong
This is a small, early-stage observational study with only 21 participants. It is not testing a treatment, so it may not lead directly to any therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Feb 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women of all races or ethnicity * Age 18-60 * Healthy volunteers or previously diagnosed with POTS by current consensus criteria (rise in heart rate of at least 30 beats/minute within 10 minutes of standing; absence of orthostatic hypotension defined as a drop in blood pressure greater than 20/10 mmHg within 3 minutes of standing; and presence of daily orthostatic symptoms for at least 6 months such as lightheadedness, dizziness, nausea, and palpitations). * Healthy participants must have cognitive testing scores within normal range (defined by Stroop word-color test score between 40-70) and be able to tolerate lower body negative pressure. * POTS participants must have either mild cognitive dysfunction (defined by Stroop word-color t-score \<40 and \>30) or normal cognitive function (defined by Stroop word-color test score between 40-70), and able to tolerate lower body negative pressure. * Capable of giving informed consent * Fluent in written and spoken English Exclusion Criteria: * Age \<18 years or \>60 years * Pregnant or breastfeeding women * Left handedness * Require glasses for vision correction (contact lenses are okay) * Current smokers * Alcohol or drug abuse * Recreational drug use (e.g. cannabis, heroin, cocaine) * Other potential causes for tachycardia (e.g. prolonged bed rest, dehydration) * Taking selective norepinephrine reuptake inhibitors or stimulant medications within the past 3 months as these may alter cognition * Unable to tolerate an MRI scanner (e.g. claustrophobia, implanted metal) * Unable to give or withdraw informed consent

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Conditions

The condition(s) this trial relates to.

postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postural tachycardia syndrome

Contacts and locations

Locations

  • Penn State Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033, United States

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Other studies related to the condition(s) this trial covers.