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Could Huntington's disease start in childhood? new study investigates

NCT ID NCT01860339

Knowledge-focused Sponsor: Peggy C Nopoulos Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at brain structure and function in children, teens, and young adults (ages 6-30) who have a parent or grandparent with Huntington's disease. Researchers used MRI scans and cognitive tests to compare those who carry the gene mutation with those who do not. The goal was to see if brain changes appear early in life, long before symptoms start.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study finds early brain differences in gene carriers, it could help us understand when Huntington's disease really begins and point to earlier intervention windows.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all at-risk individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

488 people

The number who actually took part.

Started

Jul 2005

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Young people ages 6-30 years old who have a parent or grandparent that has been diagnosed with Huntington's Disease

Ages

6 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Family history of Huntington's Disease * Age 6-30 years * Age-appropriate knowledge of HD and personal risk Exclusion Criteria: * Metal in body, including braces * History of head trauma, brain tumor, seizures, epilepsy * History of major surgery and/or significant ongoing medical issue(s)

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Conditions

The condition(s) this trial relates to.

Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Huntington's disease

Contacts and locations

Locations

  • Children's Hospital of Philadelphia with the University of Pennsylvania

    Philadelphia, Pennsylvania, 19146, United States

  • Columbia University Medical Center

    New York, New York, 10027, United States

  • University of California Davis

    Sacramento, California, 95817, United States

  • University of Iowa Hospitals and Clinics, Department of Psychiatry

    Iowa City, Iowa, 52242, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.