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Brain boosters: could lifestyle changes and memory aids stave off Alzheimer's?

NCT ID NCT05027789

Symptom relief Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether teaching memory strategies and promoting exercise, mental activities, and stress management can help older adults with memory concerns keep their thinking sharp. About 263 people aged 65 and older with normal cognition but subjective memory worries will join either a self-guided or structured group. The structured group uses a digital app to track progress. Researchers will measure memory, attention, and daily function over a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
memory support training and lifestyle modifications (exercise, mental activities, stress management)
What this could lead to
If successful, this could point toward a practical, non-drug way to help older adults maintain memory and thinking skills as they age.
What could go wrong
This is a behavioral study, not a drug trial, so effects may be modest. Results depend on participants sticking with the program, and it's unclear if benefits will last beyond the study period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 263 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2021

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The target population is cognitively normal older adults with Subjective Cognitive Concerns (SCC). SCC will be operationalized as 1. a positive complaint in response to the question: 'Have you experienced a decline in your memory or other aspect of thinking in the last 1-3 years that seems worse than others of your age' 2. normal cognition on the modified Telephone Interview of Cognitive Status (mTICS) 3. independent function in daily life. * Age 65 or older * English speaking * Lower level of engagement in healthy lifestyle behaviors and compensation use at study baseline (i.e., broadly defined as not a regular exerciser) * Approval from primary care (due to physical exercise component of the intervention) * Open to utilizing digital tools such as a digital calendar in daily life Exclusion Criteria: * Known diagnosis of dementia or cognitive impairment; * Other known neurological condition with potential to affect cognition (e.g., Parkinson's disease) * Reported history of severe psychiatric disorder (e.g., self-reported history of bipolar disorder or schizophrenia or other psychotic disorder) * Inability to complete the study protocols due to severe vision or hearing difficulties. * Has previously participated in a previous version of Brain Boosters, or another study utilizing the Digital Memory Notebook (DMN) application or EMMA.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Memory Disorders subjective cognitive decline

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive impairment Memory disorders

Contacts and locations

Locations

  • University of California, Davis Alzheimer's Disease Center

    Sacramento, California, 95817, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.