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Brain blood flow study aims to uncover clues about aging

NCT ID NCT06629077

Knowledge-focused Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 2 times

Summary

This study looks at how brain blood flow changes when healthy adults aged 55-69 breathe differently or shift posture, using MRI scans. Participants will also receive a single dose of prazosin or a placebo to see how it affects blood flow. The goal is to better understand the brain's response to reduced blood flow, which could inform future research on age-related conditions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Prazosin
What this could lead to
If successful, this could help scientists understand how brain blood flow changes with age and posture, potentially guiding future treatments for conditions like dizziness or fainting.
What could go wrong
This is a small, early-phase study with only 36 participants, so results may not apply to everyone. Prazosin can cause dizziness or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 69 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between the ages of 55-69 years * Have a BMI less than or equal to 34.5 kg/m2 * Nonsmoker * are less than 72 in (182.88 cm) height * Females must be postmenopausal Exclusion Criteria: * Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD) * History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis * History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia * Uncontrolled hypertension * History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease * Severe untreated obstructive sleep apnea * History of diabetes with HbA1c greater than 9.5% * Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.) * Current or recent (\<1 year) major psychiatric condition (Axis I) or addictive disorders * Significant surgical history * Other significant medical conditions at investigators' discretion * Contraindications to MRI * Prescribed medications that interfere with prazosin * Lactose allergy * lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebrovascular circulation Magnetic resonance imaging

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Wisconsin

    RECRUITING

    Madison, Wisconsin, 53705, United States

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