Hormone-Brain link explored in new study

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: The investigators will recruit healthy young (18-40 years) males (n = 25) and females (n = 25). Females must be naturally cycling (i.e., no oral or hormonal contraceptives), not pregnant, and premenopausal. Participants must be normotensive (\<140/90 mmHg \& \>90/60 mmHg) and have no medical history of cerebrovascular, cardiopulmonary, cardiovascular, neuromuscular, and renal disease assessed by a study questionnaire. A recent physical examination (within 1 year of participation) from a family physician or a completed physical examination by the study doctor is required prior to participation. All subjects will sign an informed consent form prior to participation. Participants will be excluded if they meet any of the following criteria: * Hypertensive (≥140/90 mmHg) or hypotensive (≤90/60 mmHg) * BMI ≥ 30 kg/m2 * Fasting blood glucose ≥ 100 mg/dL * Abnormal results on standard blood hematology tests (e.g., complete blood count, comprehensive metabolic panel) * Males with hypogonadism (total testosterone ≤ 262 ng/dL, per Endocrine Society recommendations) * Any history of cerebrovascular, cardiopulmonary, cardiovascular, neuromuscular, or renal disease * Any liver dysfunction or disease * Taking any cardiovascular medications or medications that would interfere with study medications (e.g., strong organic anion transporting polypeptide 1B1 inhibitors) * Contraindications or sensitivities to study medications * Current eating disorder (defined as \>2 on the 'SCOFF' questionnaire 67) * Current smokers * Females with an irregular menstrual cycle or any medical conditions affecting the menstrual cycle (normal cycle defined as 21-35 days from menstrual cycle diary) * Females who are pregnant (assessed with pregnancy test at screening and prior to starting medications), breastfeeding, or planning to conceive within 3 months * Females using hormonal birth control (Copper intrauterine devices \[IUDs\] will be allowed as they do not change systemic hormone levels) * Females who are peri- or postmenopausal (as determined by STRAW criteria 68) * History of hormone-sensitive cancers (i.e., breast, ovarian, uterine or prostate) * Z-score \< -2 as assessed with DXA scan (to determine risk of decrease in bone mineral density) * Assessed using the Center for Epidemiologic Studies Depression (CES-D) scale, participants with a score \> 16 at screening unless otherwise approved by the study MD