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Aiming to save more noses: refining radiation for nasal cancer

NCT ID NCT07801690

Disease control Sponsor: Radboud University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study tracks adults with squamous cell carcinoma of the nasal vestibule who receive brachytherapy, a type of radiation placed directly into the tumor. Researchers will record treatment techniques, radiation doses, and outcomes like tumor control, side effects, and patient satisfaction. The goal is to find the best ways to deliver brachytherapy to maximize cure rates and preserve the nose's appearance and function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Brachytherapy (interventional radiotherapy), a procedure where a radioactive source is placed directly into or near the tumor
What this could lead to
If it works, this could refine brachytherapy dosing and technique, improving tumor control and nose preservation while reducing side effects for people with nasal vestibule cancer.
What could go wrong
This is an observational registry, not a controlled trial, so it cannot prove which technique is best. Results depend on real-world practice variations and may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2034

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients referred for primary brachytherapy for cancer of the nasal vestibule in the participating institutes will be asked to participate.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Aged 18 years or older * Rome stage 1-4 / Wang Stage T1 -T3 * Staging of the neck by ultrasound/FNAC and/or (FDG-PET)CT and/or MRI is performed * Brachytherapy with curative intent as sole treatment for the primary tumor * Suitable to undergo brachy procedure, based on clinical judgment Exclusion criteria * Other primary tumor, except bcc skin or curatively treated cancer \> 3 years before inclusion * Previous radiotherapy to the treated area * Distant metastasis * Inability to comply with study procedures, including filling out treatment related questionnaires and to comply with scheduled follow-up visits * Non-squamous cell histology * Combinations with systemic therapy * Combination to EBRT and brachytherapy to primary tumor

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carcinoma nasal vestibule

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Radboud university medical center

    Nijmegen, 6500HB, Netherlands