Aiming to save more noses: refining radiation for nasal cancer
NCT ID NCT07801690
First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time
Summary
This study tracks adults with squamous cell carcinoma of the nasal vestibule who receive brachytherapy, a type of radiation placed directly into the tumor. Researchers will record treatment techniques, radiation doses, and outcomes like tumor control, side effects, and patient satisfaction. The goal is to find the best ways to deliver brachytherapy to maximize cure rates and preserve the nose's appearance and function.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Brachytherapy (interventional radiotherapy), a procedure where a radioactive source is placed directly into or near the tumor
- What this could lead to
- If it works, this could refine brachytherapy dosing and technique, improving tumor control and nose preservation while reducing side effects for people with nasal vestibule cancer.
- What could go wrong
- This is an observational registry, not a controlled trial, so it cannot prove which technique is best. Results depend on real-world practice variations and may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2034
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All patients referred for primary brachytherapy for cancer of the nasal vestibule in the participating institutes will be asked to participate.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: * Aged 18 years or older * Rome stage 1-4 / Wang Stage T1 -T3 * Staging of the neck by ultrasound/FNAC and/or (FDG-PET)CT and/or MRI is performed * Brachytherapy with curative intent as sole treatment for the primary tumor * Suitable to undergo brachy procedure, based on clinical judgment Exclusion criteria * Other primary tumor, except bcc skin or curatively treated cancer \> 3 years before inclusion * Previous radiotherapy to the treated area * Distant metastasis * Inability to comply with study procedures, including filling out treatment related questionnaires and to comply with scheduled follow-up visits * Non-squamous cell histology * Combinations with systemic therapy * Combination to EBRT and brachytherapy to primary tumor
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Radboud university medical center
Nijmegen, 6500HB, Netherlands