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Botox breakthrough? study tests if injection depth matters for wrinkle treatment

NCT ID NCT05766683

Symptom relief Sponsor: Henry Ford Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares injecting Botox at two different depths (2mm vs 4mm) to treat frown lines between the eyebrows. Twenty adults will receive a one-time treatment, and researchers will measure how well each depth reduces wrinkles and any side effects. The goal is to find the optimal injection depth for best results with minimal risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
onabotulinumtoxinA (Botox)
What this could lead to
If it works, this could help doctors choose the best injection depth for treating frown lines with Botox, possibly improving results and reducing side effects.
What could go wrong
This is a very small, early-phase trial with only 20 people. The results may not apply to everyone, and the difference between depths might be small or not meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

20 people

The number who actually took part.

Started

Mar 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient age 18 and older 2. Patient able to understand requirements of the study and risks involved 3. Patient able to sign a consent form Exclusion Criteria: 1. A patient who is lactating, pregnant, or planning to become pregnant 2. Prior history of botulinum neurotoxin treatment of the face within the past one (1) year 3. History of hypersensitivity to botulinum neurotoxin 4. History of neuromuscular disorders (e.g., myasthenia gravis) 5. History of facial surgery or scars in the treatment area that may confound study results

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glabellar frown lines

Contacts and locations

Locations

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

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