Facial workouts after botox: do they boost wrinkle smoothing?
NCT ID NCT01688076
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study looks at whether purposely contracting forehead muscles after Botox injections changes how quickly the treatment works, how well it reduces wrinkles, and how long the effect lasts. Researchers will inject Botox into the foreheads of 25 healthy adults aged 18–65 who already plan to get the treatment. Participants will be photographed over several months, and a dermatologist will rate wrinkle severity without knowing when each photo was taken. The goal is to see if muscle movement can improve cosmetic outcomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Botulinum Toxin A (Botox)
- What this could lead to
- If muscle contraction speeds up or extends Botox's effects, people may get better wrinkle results from the same injection.
- What could go wrong
- This is a small, early-phase study with only 25 people. Results may not apply to everyone, and side effects like bruising or drooping are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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25 people
The number who actually took part.
- Start date
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Jan 2012
- Finished
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Mar 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * In good health * Is 18-65 years of age * Has static and dynamic forehead/glabellar wrinkles * Has decided to receive Botox® treatment for their forehead/glabellar wrinkles * Has the willingness and ability to understand and provide informed consent and communicate with the investigator * Is willing to return for follow-up visits Exclusion Criteria: * Pregnant or lactating * Has received the following treatments in the forehead or glabellar region: * botulinum toxin injections in the past 6 months * ablative laser procedure in the past 6 months * radiofrequency device treatment in the past 6 months * ultrasound device treatment in the past 6 months * medium to deep chemical peel in the past 6 months * temporary soft tissue augmentation material in the past year * semi-permanent soft tissue augmentation material in the past 2 years * permanent soft tissue augmentation material * Is planning to receive within the next year, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) in the forehead or glabellar region. * Is planning to use tretinoin or retinoic acid in the next year * Has an active infection in the forehead or glabellar region (excluding mild acne) * Is allergic to cow's-milk protein * Is allergic to albumin * Taking aminoglycoside * Is currently using anticoagulation therapy * Has a history of bleeding disorders * Is unable to understand the protocol or to give informed consent * Is unable to return for follow-up visits * Has a mental illness
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Northwestern University Feinberg School of Medicine, Department of Dermatology
Chicago, Illinois, 60611, United States