Botox shots help kids with cerebral palsy move better?
NCT ID NCT06583343
First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times
Summary
This study looked at whether Botox injections, combined with physical therapy, can improve selective motor control (the ability to move one joint at a time) in children with spastic diplegia cerebral palsy. Forty children aged 4-12 received Botox in their spastic muscles plus 30 sessions of physical therapy. Researchers measured changes in leg and arm movement control and pain levels. The goal is to see if this combination can help children move more smoothly and with less discomfort.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Botulinum toxin A (Botox)
- What this could lead to
- If successful, this could point toward a way to improve movement control and reduce pain in children with cerebral palsy.
- What could go wrong
- This is a small, completed Phase 4 trial with only 40 participants, so results may not apply to all children. Botox injections carry risks like muscle weakness or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
40 people
The number who actually took part.
- Started
-
Aug 2022
- Finished
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Apr 2024
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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4 to 12 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients diagnosed with Cerebral Palsy * Between the ages of 4-12 * GMFCS (Gross Motor Function Classification System)1-4 * Patients who have received an appropriate indication for BoNT-A injection from an experienced physiatrist * Patients who have not had botulinum toxin administered in the last 6 months Exclusion Criteria: * Mental retardation * GMFCS 5 * Have an intrathecal baclofen pump for spasticity treatment or history of soft tissue and/or bone surgery * Underwent dorsal rhizotomy * Have an active infection or a localized skin infection at the injection site * Using aminoglycoside antibiotics * Contracture
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Gaziosmanpasa Research and Education Hospital
Istanbul, Gaziosmanpaşa, 34255, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.