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Fat cells used to regrow jaw bone in first human trial

NCT ID NCT02842619

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tested a new treatment called BonoFill-II, which uses a patient's own fat cells to help rebuild bone in the jaw. The study included 27 people who needed bone grafts for dental implants or after cyst removal. Doctors transplanted the cell-based material into the jaw and then checked for safety and bone growth using X-rays or CT scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
BonoFill-II (patient's own fat-derived cells)
What this could lead to
If successful, this could offer a new way to regrow bone in the jaw using a patient's own cells, potentially avoiding the need for bone from other parts of the body.
What could go wrong
This is an early-phase trial with only 27 people, so results may not apply widely. The treatment involves surgery and there is a risk of infection or the bone not growing enough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

27 people

The number who actually took part.

Started

Jul 2016

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: GENERAL 1. Subject in general good health in the opinion of the investigator as determined by medical history, vital signs physical examination and safety lab tests 2. Subject has a rehabilitation dentist and rehabilitation program 3. Up to date panoramic X-Ray/CT 4. Subject has provided written informed consent to participate in the study, understands all study procedures and agrees to follow up procedures 5. Subject is in good oral hygiene condition as per investigator's discretion SINUS AUGMENTATION 1. The subjects requires sinus augmentation as per investigator's discretion 2. Healthy condition of Maxillary Sinuses and Oral Mucosa determined by X-ray BONE GRAFTING AFTER REMOVAL OF CYSTS FROM JAWS 1. Subject who according to investigator diagnosis required removal of cysts from jaws. Limited to cysts diagnosed as: radicular cysts, residual cysts, congenital cysts, developmental and acquired cysts. 2. Subject's cyst was removed after diagnosis of the cyst type Exclusion Criteria: 1. Subject with a recorded medical history of diseases such as diabetes mellitus, heart diseases, renal failure, osteoporosis, Multiple sclerosis, 2. Subject treated with systemic steroids 3. Subject with a known autoimmune disease, such as Addison's disease, Myasthenia gravis, Pernicious anemia, Reactive arthritis, Rheumatoid arthritis, Sjogren syndrome, Systemic lupus erythematosus, Type I diabetes. 4. Subject has vitiligo or a known scar healing problems (keloid formation) 5. Subject treated with Oral Bisphosphonate drugs (such as Fosalan and other similar medications) 6. Subjects underwent one of the following treatments up to 12 months prior to Visit 1: Chemotherapy, Radiotherqapy 7. In case of sinus augmentation - unhealthy conditions of Maxillary Sinuses. 8. Subject with current active infection or illness. 9. Subject participating in another clinical trial 30 days prior to and during the study period. 10. Subject is a pregnant or lactating woman. Pregnancy will be verified by urine test during screening. 11. Subject has a known history of any significant medical disorder, which in the investigator's discretion contraindicates the subject's participation. 12. Subject has a known allergy for anesthesia. 13. Subjects with known allergy to hyaluronic acid. 14. Subjects with known allergy to HypoThermosol® or Dextran-40. 15. Subjects with known allergy to any of the antibiotics: Bacitracin, Gentamicin and/or Polymyxin B Sulfate. 16. Positive serology for either HIV, hepatitis B or hepatitis C. 17. Abnormal clinically significant laboratory test and exams findings as per investigator's discretion.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Oral and Maxillofacial Surgery Clinic - Beit Merik

    Kfar Saba, Israel

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