Fat cells used to regrow jaw bone in first human trial

NCT ID NCT02842619

Completed Disease control Sponsor: BonusBio Group Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tested a new treatment called BonoFill-II, which uses a patient's own fat cells to help rebuild bone in the jaw. The study included 27 people who needed bone grafts for dental implants or after cyst removal. Doctors transplanted the cell-based material into the jaw and then checked for safety and bone growth using X-rays or CT scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BonoFill-II (patient's own fat-derived cells)
What this could lead to: If successful, this could offer a new way to regrow bone in the jaw using a patient's own cells, potentially avoiding the need for bone from other parts of the body.
What could go wrong: This is an early-phase trial with only 27 people, so results may not apply widely. The treatment involves surgery and there is a risk of infection or the bone not growing enough.

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Conditions

The condition(s) this trial relates to.

solitary bone cyst

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE AUGMENTATION BONE GRAFTS

Contacts and locations

Locations

Oral and Maxillofacial Surgery Clinic - Beit Merik

Kfar Saba, Israel

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