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Tiny study hopes to unlock bone healing genes in dental grafts

NCT ID NCT06156488

Knowledge-focused Sponsor: Universidad de Granada Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 15, 2026 · Updated 4 times

Summary

This completed study looked at how genes involved in bone regeneration behave when a common bone graft material is used alone or combined with hyaluronic acid and polynucleotides. Five people needing sinus lifts for dental implants participated. Researchers analyzed gene activity in the regenerated bone six months after grafting to see if the added substances changed the healing process.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
anorganic bovine bone graft with polynucleotides and hyaluronic acid
What this could lead to
If successful, this could help identify which genes are important for bone regeneration, potentially leading to better dental bone graft materials.
What could go wrong
This is a very small, early study with only 5 participants, so results may not apply to everyone. It looks at gene activity, not actual bone healing outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

5 people

The number who actually took part.

Started

Sep 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Totally edentulous maxilla or Kennedy class I in the upper jaw. * Less than 5 mm of residual crestal bone to the maxillary sinus. * Need for the replacement of teeth with dental implants. Exclusion Criteria: * Sinus pathology (sinusitis, mucocele, cysts). * Heavy smokers (\>10 cigarettes/day). * Previous long-term (\>3 months) use of drugs known to affect bone metabolism, such as bisphosphonates.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sinus floor augmentation

Contacts and locations

Locations

  • Universidad de Granada

    Granada, Granada, 18009, Spain

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