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New technique may boost ACL recovery: blood flow restriction plus PT shows promise

NCT ID NCT06437470

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether adding blood flow restriction (BFR) to standard physical therapy helps people recover better after anterior cruciate ligament (ACL) reconstruction. Thirty participants, aged 18 to 35, were split into two groups: one received standard PT with a sham cuff, the other received PT plus BFR at 80% of limb occlusive pressure. The study measured knee function, balance, strength, and swelling to see if BFR offers extra benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood flow restriction technique
What this could lead to
If this approach works, it could improve knee recovery after ACL surgery, helping people regain strength and function faster.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply to everyone. The technique is still experimental and needs larger trials to confirm benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

May 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged from 18-35 years. 2. Underwent an ACLR semitendinosus autograft one-week post-operative 3. Willingness to participate in the intervention and subsequent assessment. 4. BMI from 18.5 to 29.9 kg/m2. Exclusion Criteria: 1. Insecure graft fixation (due to bone quality, suspension). 2. Active infection. 3. Postsurgical excess knee swelling that may limit exercise performance. 4. ACLR using bone tendon bone (BTB) graft. 5. Any cardiovascular disease such as hypertension. 6. Any lower limb trauma. 7. Hip and ankle pathology. 8. BMI more than 30 kg/m2

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament injuries

Contacts and locations

Locations

  • Faculty of physical therapy - Cairo University

    Cairo, Giza Governorate, 12613, Egypt

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