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Immunotherapy boosts bladder cancer treatment in major trial

NCT ID NCT03775265

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 28, 2026 · Updated 9 times

Summary

This Phase III trial tests whether adding the immunotherapy drug atezolizumab to standard chemoradiotherapy helps people with muscle-invasive bladder cancer that hasn't spread. About 475 participants receive either chemoradiotherapy alone or with atezolizumab. The main goal is to see if the combination keeps the bladder cancer from returning or getting worse.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Atezolizumab (immunotherapy drug) plus chemotherapy (gemcitabine, cisplatin, fluorouracil, mitomycin-C) and radiation therapy
What this could lead to
If successful, this could offer a more effective treatment option for localized muscle-invasive bladder cancer, potentially helping patients avoid bladder removal surgery.
What could go wrong
This is a Phase III trial, but results are not yet available. Adding immunotherapy may increase side effects without improving outcomes, and the benefit may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 475 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2019

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * STEP 1 REGISTRATION: If this will be the first patient from a registering site to receive a given RT modality (3DCRT vs. IMRT), the site must first submit pre-RT planning documents within 3 days of Step 1 registration and receive approval from Imaging and Radiation Oncology Core (IROC) before randomizing the patient to Step 2. If this will not be the first patient to receive a specific RT modality, the patient should be immediately randomized to Step 2 on the same day. * STEP 2 RANDOMIZATION: If patient required review of pre-RT planning, randomization must occur within 14 days of initial registration. * Patients must have histologically proven, T2-T4a N0M0 urothelial carcinoma of the bladder within 120 days prior to randomization and no intervening treatment between the histologic proof and randomization. Patients with mixed urothelial carcinoma will be eligible for the trial, but the presence of small cell carcinoma will make a patient ineligible. Patients with lymph nodes \>= 1.0 cm in shortest cross-sectional diameter on imaging (computed tomography \[CT\]/magnetic resonance imaging \[MRI\] of abdomen and pelvis) must have a biopsy of the enlarged lymph node showing no tumor involvement within 70 days prior to randomization. These patients may be suitable for neoadjuvant chemotherapy and radical cystectomy and are eligible for this trial if they seek out a bladder sparing treatment strategy, however patients who have received prior systemic chemotherapy for bladder cancer are not eligible for the trial. * Patients must undergo a transurethral resection of bladder tumor (TURBT) within 70 days prior to randomization. In a situation where a patient is referred from outside to the enrolling institution, patient must have a repeat office cystoscopy by the urologist who will be following the patient on the clinical trial to assess the adequacy of the prior TURBT. This cystoscopy can be performed in urologist office without general anesthesia. Patient may then undergo repeat TURBT if deemed necessary as standard of care by the treating urologist. Patients may have either completely or partially resected tumors as long as the treating urologist attempted maximal resection. Patient must not have T4b disease * Patients must undergo radiological staging within 70 days prior to randomization. Imaging of chest, abdomen, and pelvis must be performed using CT or MRI. Patients must not have evidence of T4bN1-3 disease. Eligibility is based on the local radiology report. * Patients with hydronephrosis are eligible if they have unilateral hydronephrosis and kidney function meets criteria specified. * Patients must not have had urothelial carcinoma or histological variant at any site outside of the urinary bladder within the previous 24 months except Ta/T1/carcinoma in situ (CIS) of the upper urinary tract including renal pelvis and ureter if the patient had undergone complete nephroureterectomy. * Patients must not have diffuse CIS based on cystoscopy and biopsy. * Patient must be planning to receive one of the protocol specified chemotherapy regimens. * All adverse events associated with any prior surgery and intravesical therapy must have resolved to Common Terminology Criteria for Adverse Events (CTCAE) grade =\< 2 prior to randomization. * Patient must not have received any systemic chemotherapy for their bladder cancer. * Patient must not have had prior pelvic radiation. * Patients must not have received prior treatment for muscle invasive bladder cancer including neoadjuvant chemotherapy for the current tumor. * Patients must not have received any systemic therapy (including, but not limited to, interferon alfa-2b, high dose IL-2, pegylated interferon \[PEG-IFN\], anti-PD-1, anti-PD-L1), for non-muscle invasive bladder cancer. Prior intravesical bacillus Calmette-Guerin (BCG), interferon, and intravesical chemotherapy are allowed. * Patients must not have received any of the following prohibited therapies within 28 days prior to randomization or be planning to receive any of the following prohibited therapies during protocol treatment: * Anti-cancer systemic chemotherapy or biological therapy not specified in the protocol. * Immunotherapy not specified in this protocol. * Systemic or intravesical use of any non-study anti-cancer agent (investigational or non-investigational). * Investigational agents other than atezolizumab. * Live vaccines: Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, BCG, and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g. Flu-Mist®) are live attenuated vaccines, and are not allowed. Prior administration of intravesical BCG is allowed. * Glucocorticoids for any purpose other than to modulate symptoms from an event of suspected immunologic etiology. The use of physiologic doses of corticosteroids (defined as 10 mg prednisone) are acceptable, however site investigators should consult with the study chair for any dose higher than 10 mg prednisone. Dexamethasone 4 mg IV with chemotherapy to prevent nausea is allowed. * RANKL infusion: Concurrent denosumab (which binds the cytokine RANKL) for any known indication is prohibited due to interaction with study medication. * Patients must not have a major surgical procedure within 28 days prior to randomization. If patient had any surgical procedure then they should have recovered to full presurgical performance status and surgical adverse events should have resolved to grade =\< 2. TURBT is not considered a major surgical procedure. * Patients must not have received treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor \[anti-TNF\] agents) within 14 days prior to randomization. Exceptions: * Patients may have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea). * The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension or adrenocortical insufficiency is allowed. Physiological doses equivalent of 10 mg prednisone daily are allowed. Short term steroids given as antiemetic therapy, e.g. 4 mg dexamethasone or equivalent once a week, is allowed. * Patients must not have received a live, attenuated vaccine within 4 weeks prior to randomization or anticipate that such a live, attenuated vaccine will be required while on protocol treatment and up to 5 months after the last dose of protocol treatment. * Inactivated influenza vaccination should be given during influenza season only (approximately October to March). Patients must not receive live, attenuated influenza vaccine within 4 weeks prior to randomization or while on protocol treatment and up to 5 months after the last dose of protocol treatment. * Patients must not have undergone prior allogeneic bone marrow transplantation or prior solid organ transplantation. * Patients must be \>= 18 years of age * Patient may or may not be radical cystectomy candidates. * Absolute neutrophil count (ANC) \>= 1,500/microliter (mcL) (within 28 days prior to randomization). * Platelets \>= 100,000/mcL (within 28 days prior to randomization). * Hemoglobin \>= 9 g/dL (within 28 days prior to randomization). * Total bilirubin =\< 1.5 x institutional upper limit of normal (IULN) (except patients with Gilbert's syndrome, who must have a total bilirubin \< 3.0 mg/dL) (within 28 days prior to randomization). * Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \< 2.5 x IULN (within 28 days prior to randomization). * Patients must not have clinically significant liver disease that precludes patient from treatment regimens prescribed on the study (including, but not limited to, active viral, alcoholic or other autoimmune hepatitis, cirrhosis or inherited liver disease). * Patients must have adequate renal function as evidenced by calculated creatinine clearance \>= 25 mL/min. The creatinine used to calculate the clearance result must have been obtained within 28 days prior to randomization. * Patients must have Zubrod performance status =\< 2. * Patients must have a baseline electrocardiography (ECG) performed within 30 days prior to randomization. * Patient must not have history of idiopathic pulmonary fibrosis, pneumonitis (including drug induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis. * Patients must not have an active infection requiring oral or IV antibiotics within 14 days prior to randomization. Patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are not eligible. If patient develops urinary tract infection after TURBT they must have recovered from the infection prior to registration. * Patients must not have active autoimmune disease that has required systemic treatment in past two years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment. Autoimmune diseases include, but are not limited to, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, Graves' disease treated with methimazole or glomerulonephritis. * Patient must not have a history of active tuberculosis. * If patient has a known history of hepatitis B virus (HBV) or hepatitis C virus (HCV), they must meet the following criteria within 28 days prior to randomization. * Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen \[HBsAg\] test and a positive anti-HBc \[antibody to hepatitis B core antigen\] antibody test) are eligible. * Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV ribonucleic acid (RNA). * Patients who are known to be positive for human immunodeficiency virus (HIV) are eligible only if they have all of the following: * A stable regimen of highly active anti-retroviral therapy (HAART) * No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections * A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests within 28 days prior to randomization. * No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for two years. Patients with localized prostate cancer who are being followed by an active surveillance program are also eligible. * Female patients of childbearing potential must have a serum pregnancy test prior to randomization. Patients must not be pregnant or nursing due to the potential teratogenic side effects of the protocol treatment. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of protocol treatment, and for 5 months (150 days) after the last dose of all study drugs. A woman is considered to be of "reproductive potential" if she has had a menses at any time in the preceding 12 consecutive months. * Patients must not be known to be allergic to Chinese hamster egg or ovary cell products and must not have any known major allergic reactions to any study drug. * Patients must be offered the opportunity to participate in specimen banking for future studies. * Patients who can complete Patient-Reported Outcome instruments in English or Spanish must agree to complete the EORTC QLQ-C30, the EORTC QLQ-BLM30, the EPIC Bowel Assessment, and the EQ-5D-5L per protocol schedule of assessment. * As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.

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Conditions

The condition(s) this trial relates to.

bladder transitional cell carcinoma infiltrating bladder urothelial carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bladder urothelial carcinoma Muscle-invasive bladder carcinoma Stage II bladder cancer ajcc V8 Stage IIIA bladder cancer ajcc V8

Contacts and locations

Locations

  • AMG Crystal Lake - Oncology

    Crystal Lake, Illinois, 60014, United States

  • AMG Libertyville - Oncology

    Libertyville, Illinois, 60048, United States

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, 60453-2699, United States

  • Advocate Good Samaritan Hospital

    Downers Grove, Illinois, 60515, United States

  • Advocate Good Shepherd Hospital

    Barrington, Illinois, 60010, United States

  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois, 60657, United States

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068, United States

  • Advocate Sherman Hospital

    Elgin, Illinois, 60123, United States

  • Advocate South Suburban Hospital

    Hazel Crest, Illinois, 60429, United States

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California, 94704, United States

  • Arnold Palmer Cancer Center Medical Oncology Norwin

    N. Huntingdon, Pennsylvania, 15642, United States

  • Ascension All Saints Hospital-Spring Street-Racine

    Racine, Wisconsin, 53405, United States

  • Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh

    Oshkosh, Wisconsin, 54904, United States

  • Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton

    Appleton, Wisconsin, 54915, United States

  • Ascension Via Christi Hospitals Wichita

    Wichita, Kansas, 67214, United States

  • Aspirus Cancer Care - Stevens Point

    Stevens Point, Wisconsin, 54481, United States

  • Aspirus Cancer Care - Wisconsin Rapids

    Wisconsin Rapids, Wisconsin, 54494, United States

  • Aspirus Cancer Care-Antigo-Volm Cancer Center

    Antigo, Wisconsin, 54409, United States

  • Aspirus Cancer Care-Wausau

    Wausau, Wisconsin, 54401, United States

  • Aspirus Medford Hospital

    Medford, Wisconsin, 54451, United States

  • Augusta Health Center for Cancer and Blood Disorders

    Fishersville, Virginia, 22939, United States

  • Aurora Bay Area Medical Group-Marinette

    Marinette, Wisconsin, 54143, United States

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin, 54311, United States

  • Aurora Cancer Care-Grafton

    Grafton, Wisconsin, 53024, United States

  • Aurora Cancer Care-Kenosha South

    Kenosha, Wisconsin, 53142, United States

  • Aurora Cancer Care-Milwaukee

    Milwaukee, Wisconsin, 53209, United States

  • Aurora Cancer Care-Milwaukee West

    Wauwatosa, Wisconsin, 53226, United States

  • Aurora Cancer Care-Racine

    Racine, Wisconsin, 53406, United States

  • Aurora Cancer Care-Southern Lakes VLCC

    Burlington, Wisconsin, 53105, United States

  • Aurora Health Care Germantown Health Center

    Germantown, Wisconsin, 53022, United States

  • Aurora Medical Center in Summit

    Summit, Wisconsin, 53066, United States

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Aurora Sinai Medical Center

    Milwaukee, Wisconsin, 53233, United States

  • Aurora West Allis Medical Center

    West Allis, Wisconsin, 53227, United States

  • Banner North Colorado Medical Center

    Greeley, Colorado, 80631, United States

  • Banner North Colorado Medical Center - Loveland Campus

    Loveland, Colorado, 80539, United States

  • Banner University Medical Center - Tucson

    Tucson, Arizona, 85719, United States

  • Baptist Health Lexington

    Lexington, Kentucky, 40503, United States

  • Baptist Health Louisville

    Louisville, Kentucky, 40207, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Beebe Health Campus

    Rehoboth Beach, Delaware, 19971, United States

  • Beebe South Coastal Health Campus

    Millville, Delaware, 19967, United States

  • Bellin Memorial Hospital

    Green Bay, Wisconsin, 54301, United States

  • Benefis Sletten Cancer Institute

    Great Falls, Montana, 59405, United States

  • Billings Clinic Cancer Center

    Billings, Montana, 59101, United States

  • Bozeman Health Deaconess Hospital

    Bozeman, Montana, 59715, United States

  • Bronson Battle Creek

    Battle Creek, Michigan, 49017, United States

  • CHI Health Good Samaritan

    Kearney, Nebraska, 68847, United States

  • CTCA at Southeastern Regional Medical Center

    Newnan, Georgia, 30265, United States

  • Cancer Care and Hematology-Fort Collins

    Fort Collins, Colorado, 80528, United States

  • Cancer Center of Western Wisconsin

    New Richmond, Wisconsin, 54017, United States

  • Cancer Centers of Southwest Oklahoma Research

    Lawton, Oklahoma, 73505, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carlisle Regional Cancer Center

    Carlisle, Pennsylvania, 17015, United States

  • Carolina Regional Cancer Center

    Myrtle Beach, South Carolina, 29577, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Christiana Care Health System-Concord Health Center

    Chadds Ford, Pennsylvania, 19317, United States

  • Coborn Cancer Center at Saint Cloud Hospital

    Saint Cloud, Minnesota, 56303, United States

  • Community Cancer Center East

    Indianapolis, Indiana, 46219, United States

  • Community Cancer Center North

    Indianapolis, Indiana, 46256, United States

  • Community Cancer Center South

    Indianapolis, Indiana, 46227, United States

  • Comprehensive Cancer Centers of Nevada

    Las Vegas, Nevada, 89148, United States

  • Comprehensive Cancer Centers of Nevada - Central Valley

    Las Vegas, Nevada, 89169, United States

  • Comprehensive Cancer Centers of Nevada - Northwest

    Las Vegas, Nevada, 89128, United States

  • Comprehensive Cancer Centers of Nevada - Town Center

    Las Vegas, Nevada, 89144, United States

  • Condell Memorial Hospital

    Libertyville, Illinois, 60048, United States

  • Cooper Hospital University Medical Center

    Camden, New Jersey, 08103, United States

  • Corewell Health Beaumont Troy Hospital

    Troy, Michigan, 48085, United States

  • Corewell Health Dearborn Hospital

    Dearborn, Michigan, 48124, United States

  • Corewell Health Farmington Hills Hospital

    Farmington Hills, Michigan, 48336, United States

  • Corewell Health William Beaumont University Hospital

    Royal Oak, Michigan, 48073, United States

  • CoxHealth South Hospital

    Springfield, Missouri, 65807, United States

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dartmouth Cancer Center - North

    Saint Johnsbury, Vermont, 05819, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Dayton Physician LLC - Englewood

    Dayton, Ohio, 45415, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • ECU Health Oncology Kenansville

    Kenansville, North Carolina, 28349, United States

  • ECU Health Oncology Kinston

    Kinston, North Carolina, 28501, United States

  • ECU Health Oncology Richlands

    Richlands, North Carolina, 28574, United States

  • East Jefferson General Hospital

    Metairie, Louisiana, 70006, United States

  • Edward Hines Jr VA Hospital

    Hines, Illinois, 60141, United States

  • Edward Hospital/Cancer Center

    Naperville, Illinois, 60540, United States

  • Elmhurst Memorial Hospital

    Elmhurst, Illinois, 60126, United States

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia, 30342, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308, United States

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • FHCC at EvergreenHealth

    Kirkland, Washington, 98034, United States

  • Fairview Southdale Hospital

    Edina, Minnesota, 55435, United States

  • First Physicians Group - Urology Robotic and Minimally Invasive Surgery

    Sarasota, Florida, 34239, United States

  • Florida Cancer Specialists - Sarasota

    Sarasota, Florida, 34232, United States

  • Florida Cancer Specialists - Sarasota Downtown

    Sarasota, Florida, 34239, United States

  • Fred Hutchinson Cancer Center

    Seattle, Washington, 98109, United States

  • Fremont - Rideout Cancer Center

    Marysville, California, 95901, United States

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822, United States

  • Geisinger Medical Oncology-Lewisburg

    Lewisburg, Pennsylvania, 17837, United States

  • Geisinger Wyoming Valley/Henry Cancer Center

    Wilkes-Barre, Pennsylvania, 18711, United States

  • Gibbs Cancer Center-Pelham

    Greer, South Carolina, 29651, United States

  • Good Samaritan University Hospital

    West Islip, New York, 11795, United States

  • Greater Dayton Cancer Center

    Kettering, Ohio, 45409, United States

  • Greater Regional Medical Center

    Creston, Iowa, 50801, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Hartford Hospital

    Hartford, Connecticut, 06102, United States

  • Hawaii Cancer Care - Westridge

    ‘Aiea, Hawaii, 96701, United States

  • Hawaii Cancer Care Inc - Waterfront Plaza

    Honolulu, Hawaii, 96813, United States

  • Heartland Regional Medical Center

    Saint Joseph, Missouri, 64506, United States

  • Helen F Graham Cancer Center

    Newark, Delaware, 19713, United States

  • Henry Ford Health Saint John Hospital

    Detroit, Michigan, 48236, United States

  • Henry Ford Health Warren Hospital

    Warren, Michigan, 48093, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Henry Ford Saint John Hospital - Macomb Medical

    Macomb, Michigan, 48044, United States

  • Henry Ford West Bloomfield Hospital

    West Bloomfield, Michigan, 48322, United States

  • Highland Hospital

    Rochester, New York, 14620, United States

  • Illinois CancerCare - Washington

    Washington, Illinois, 61571, United States

  • Illinois CancerCare-Bloomington

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare-Canton

    Canton, Illinois, 61520, United States

  • Illinois CancerCare-Carthage

    Carthage, Illinois, 62321, United States

  • Illinois CancerCare-Eureka

    Eureka, Illinois, 61530, United States

  • Illinois CancerCare-Galesburg

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare-Kewanee Clinic

    Kewanee, Illinois, 61443, United States

  • Illinois CancerCare-Macomb

    Macomb, Illinois, 61455, United States

  • Illinois CancerCare-Ottawa Clinic

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peoria

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Peru

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Princeton

    Princeton, Illinois, 61356, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • Kettering Medical Center

    Kettering, Ohio, 45429, United States

  • LSU Healthcare Network / Metairie Multi-Specialty Clinic

    Metairie, Louisiana, 70006, United States

  • Lehigh Valley Hospital - Muhlenberg

    Bethlehem, Pennsylvania, 18017, United States

  • Lehigh Valley Hospital-Cedar Crest

    Allentown, Pennsylvania, 18103, United States

  • Los Angeles General Medical Center

    Los Angeles, California, 90033, United States

  • Louisiana Hematology Oncology Associates LLC

    Baton Rouge, Louisiana, 70809, United States

  • Lowell General Hospital

    Lowell, Massachusetts, 01854, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • MD Anderson Cancer Center at Cooper-Voorhees

    Voorhees Township, New Jersey, 08043, United States

  • MaineHealth Cancer Care Center of York County

    Sanford, Maine, 04073, United States

  • MaineHealth Cancer Care and IV Therapy - Sanford

    Sanford, Maine, 04073, United States

  • MaineHealth Cancer Care and IV Therapy - South Portland

    South Portland, Maine, 04106, United States

  • MaineHealth Coastal Cancer Treatment Center

    Bath, Maine, 04530, United States

  • MaineHealth Maine Medical Center - Biddeford

    Biddeford, Maine, 04005, United States

  • MaineHealth Maine Medical Center - Portland

    Portland, Maine, 04102, United States

  • MaineHealth Maine Medical Center- Scarborough

    Scarborough, Maine, 04074, United States

  • MaineHealth Stephens Hospital

    Norway, Maine, 04268, United States

  • MaineHealth Waldo Hospital

    Belfast, Maine, 04915, United States

  • Margaret R Pardee Memorial Hospital

    Hendersonville, North Carolina, 28791, United States

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin, 54548, United States

  • Marshfield Medical Center - Weston

    Weston, Wisconsin, 54476, United States

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701, United States

  • Marshfield Medical Center-Marshfield

    Marshfield, Wisconsin, 54449, United States

  • Marshfield Medical Center-Rice Lake

    Rice Lake, Wisconsin, 54868, United States

  • Marshfield Medical Center-River Region at Stevens Point

    Stevens Point, Wisconsin, 54482, United States

  • Mary Bird Perkins Cancer Center

    Baton Rouge, Louisiana, 70809, United States

  • Mary Greeley Medical Center

    Ames, Iowa, 50010, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Health System-Eau Claire Clinic

    Eau Claire, Wisconsin, 54701, United States

  • Mayo Clinic Health System-Franciscan Healthcare

    La Crosse, Wisconsin, 54601, United States

  • Mayo Clinic Hospital in Arizona

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • McFarland Clinic - Ames

    Ames, Iowa, 50010, United States

  • Medical Center of the Rockies

    Loveland, Colorado, 80538, United States

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware, 19713, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Hospital North

    Colorado Springs, Colorado, 80920, United States

  • Memorial Medical Center

    Modesto, California, 95355, United States

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

  • Mercy Cancer Center - Carmichael

    Carmichael, California, 95608, United States

  • Mercy Cancer Center - Elk Grove

    Elk Grove, California, 95758, United States

  • Mercy Cancer Center - Rocklin

    Rocklin, California, 95765, United States

  • Mercy Cancer Center - Sacramento

    Sacramento, California, 95816, United States

  • Mercy Cancer Center-West Lakes

    Clive, Iowa, 50325, United States

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433, United States

  • Mercy Hospital Oklahoma City

    Oklahoma City, Oklahoma, 73120, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Mercy Hospital South

    St Louis, Missouri, 63128, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Mercy Medical Center-West Lakes

    West Des Moines, Iowa, 50266, United States

  • Mercy San Juan Medical Center

    Carmichael, California, 95608, United States

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61636, United States

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109, United States

  • Michael E DeBakey VA Medical Center

    Houston, Texas, 77030, United States

  • Michigan Healthcare Professionals Clarkston

    Clarkston, Michigan, 48346, United States

  • Michigan Healthcare Professionals Farmington

    Farmington Hills, Michigan, 48334, United States

  • Michigan Healthcare Professionals Madison Heights

    Madison Heights, Michigan, 48071, United States

  • Michigan Healthcare Professionals Pontiac

    Pontiac, Michigan, 48341, United States

  • Michigan Healthcare Professionals Troy

    Troy, Michigan, 48098, United States

  • Midstate Medical Center

    Meriden, Connecticut, 06451, United States

  • Miller-Dwan Hospital

    Duluth, Minnesota, 55805, United States

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131, United States

  • Missouri Baptist Sullivan Hospital

    Sullivan, Missouri, 63080, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Montefiore Medical Center-Einstein Campus

    The Bronx, New York, 10461, United States

  • Montefiore Medical Center-Weiler Hospital

    The Bronx, New York, 10461, United States

  • Monticello Cancer Center

    Monticello, Minnesota, 55362, United States

  • Mount Sinai Comprehensive Cancer Center at Aventura

    Aventura, Florida, 33180, United States

  • Mount Sinai Medical Center

    Miami Beach, Florida, 33140, United States

  • MultiCare Auburn Medical Center

    Auburn, Washington, 98001, United States

  • MultiCare Gig Harbor Medical Park

    Gig Harbor, Washington, 98335, United States

  • MultiCare Good Samaritan Hospital

    Puyallup, Washington, 98372, United States

  • MultiCare Tacoma General Hospital

    Tacoma, Washington, 98405, United States

  • Munson Medical Center

    Traverse City, Michigan, 49684, United States

  • MyMichigan Medical Center Saginaw

    Saginaw, Michigan, 48601, United States

  • Nebraska Medicine-Bellevue

    Bellevue, Nebraska, 68123, United States

  • Nebraska Medicine-Village Pointe

    Omaha, Nebraska, 68118, United States

  • Nebraska Methodist Hospital

    Omaha, Nebraska, 68114, United States

  • NorthShore University HealthSystem-Evanston Hospital

    Evanston, Illinois, 60201, United States

  • NorthShore University HealthSystem-Glenbrook Hospital

    Glenview, Illinois, 60026, United States

  • NorthShore University HealthSystem-Highland Park Hospital

    Highland Park, Illinois, 60035, United States

  • Northwell Health/Center for Advanced Medicine

    Lake Success, New York, 11042, United States

  • Northwest Wisconsin Cancer Center

    Ashland, Wisconsin, 54806, United States

  • Northwestern Medicine Cancer Center Delnor

    Geneva, Illinois, 60134, United States

  • Northwestern Medicine Cancer Center Kishwaukee

    DeKalb, Illinois, 60115, United States

  • Northwestern Medicine Cancer Center Warrenville

    Warrenville, Illinois, 60555, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • OSF Saint Francis Medical Center

    Peoria, Illinois, 61637, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • OptumCare Cancer Care at Charleston

    Las Vegas, Nevada, 89102, United States

  • OptumCare Cancer Care at Fort Apache

    Las Vegas, Nevada, 89183, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, 93401, United States

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, 96701, United States

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California, 94301, United States

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California, 94086, United States

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, 55416, United States

  • Parkland Health Center-Bonne Terre

    Bonne Terre, Missouri, 63628, United States

  • Penn State Milton S Hershey Medical Center

    Hershey, Pennsylvania, 17033-0850, United States

  • Penobscot Bay Medical Center

    Rockport, Maine, 04856, United States

  • Phelps Memorial Hospital Center

    Sleepy Hollow, New York, 10591, United States

  • Poudre Valley Hospital

    Fort Collins, Colorado, 80524, United States

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina, 29615, United States

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina, 29650, United States

  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii, 96813, United States

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii, 96817, United States

  • Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • Radiation Oncology Centers of Nevada Central

    Las Vegas, Nevada, 89106, United States

  • Radiation Oncology Centers of Nevada Southeast

    Las Vegas, Nevada, 89119, United States

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Reid Health

    Richmond, Indiana, 47374, United States

  • Renown Regional Medical Center

    Reno, Nevada, 89502, United States

  • Rocky Mountain Cancer Centers-Boulder

    Boulder, Colorado, 80304, United States

  • Rush MD Anderson Cancer Center

    Chicago, Illinois, 60612, United States

  • Saint Francis Medical Center

    Cape Girardeau, Missouri, 63703, United States

  • Saint Joseph Medical Center Hematology and Oncology - Silverdale

    Silverdale, Washington, 98383, United States

  • Sainte Genevieve County Memorial Hospital

    Sainte Genevieve, Missouri, 63670, United States

  • Sanford Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford Broadway Medical Center

    Fargo, North Dakota, 58122, United States

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota, 57104, United States

  • Sanford Joe Lueken Cancer Center

    Bemidji, Minnesota, 56601, United States

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Sarasota Memorial Health Care Center at University Parkway

    Sarasota, Florida, 34243, United States

  • Sarasota Memorial Hospital

    Sarasota, Florida, 34239, United States

  • Sarasota Memorial Hospital-Venice

    N. Venice, Florida, 34275, United States

  • Shaw Cancer Center

    Edwards, Colorado, 81632, United States

  • Sibley Memorial Hospital

    Washington D.C., District of Columbia, 20016, United States

  • Siteman Cancer Center at Saint Peters Hospital

    City of Saint Peters, Missouri, 63376, United States

  • Siteman Cancer Center at West County Hospital

    Creve Coeur, Missouri, 63141, United States

  • Siteman Cancer Center-South County

    St Louis, Missouri, 63129, United States

  • Smilow Cancer Hospital Care Center - Guilford

    Guilford, Connecticut, 06437, United States

  • Smilow Cancer Hospital Care Center - Waterford

    Waterford, Connecticut, 06385, United States

  • Smilow Cancer Hospital Care Center at Greenwich

    Greenwich, Connecticut, 06830, United States

  • Smilow Cancer Hospital Care Center-Trumbull

    Trumbull, Connecticut, 06611, United States

  • Spartanburg Medical Center

    Spartanburg, South Carolina, 29303, United States

  • Springfield Clinic

    Springfield, Illinois, 62702, United States

  • Springfield Memorial Hospital

    Springfield, Illinois, 62781, United States

  • State University of New York Upstate Medical University

    Syracuse, New York, 13210, United States

  • Stony Brook University Medical Center

    Stony Brook, New York, 11794, United States

  • Straub Clinic and Hospital

    Honolulu, Hawaii, 96813, United States

  • Sutter Auburn Faith Hospital

    Auburn, California, 95602, United States

  • Sutter Cancer Centers Radiation Oncology Services-Auburn

    Auburn, California, 95603, United States

  • Sutter Cancer Centers Radiation Oncology Services-Roseville

    Roseville, California, 95661, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • Sutter Roseville Medical Center

    Roseville, California, 95661, United States

  • The Cancer Center of Hawaii-Liliha

    Honolulu, Hawaii, 96817, United States

  • The Cancer Center of Hawaii-Pali Momi

    ‘Aiea, Hawaii, 96701, United States

  • The Hospital of Central Connecticut

    New Britain, Connecticut, 06050, United States

  • The James Graham Brown Cancer Center at University of Louisville

    Louisville, Kentucky, 40202, United States

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health Medical Center - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Joseph Mercy Oakland Hospital

    Pontiac, Michigan, 48341, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan, 48154, United States

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California, 92868, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

  • UCHealth Greeley Hospital

    Greeley, Colorado, 80631, United States

  • UCHealth Memorial Hospital Central

    Colorado Springs, Colorado, 80909, United States

  • UCHealth University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610, United States

  • UI Health Care Mission Cancer and Blood - Laurel Clinic

    Des Moines, Iowa, 50314, United States

  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic

    Clive, Iowa, 50325, United States

  • UM Sylvester Comprehensive Cancer Center at Coral Gables

    Coral Gables, Florida, 33146, United States

  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach

    Deerfield Beach, Florida, 33442, United States

  • UPMC Altoona

    Altoona, Pennsylvania, 16601, United States

  • UPMC Cancer Center - Monroeville

    Monroeville, Pennsylvania, 15146, United States

  • UPMC Cancer Center at UPMC Horizon

    Farrell, Pennsylvania, 16121, United States

  • UPMC Cancer Center at UPMC McKeesport

    McKeesport, Pennsylvania, 15132, United States

  • UPMC Cancer Center at UPMC Northwest

    Seneca, Pennsylvania, 16346, United States

  • UPMC Cancer Centers - Arnold Palmer Pavilion

    Greensburg, Pennsylvania, 15601, United States

  • UPMC Hillman Cancer Center

    Pittsburgh, Pennsylvania, 15232, United States

  • UPMC Hillman Cancer Center - New Castle

    New Castle, Pennsylvania, 16105, United States

  • UPMC Hillman Cancer Center Erie

    Erie, Pennsylvania, 16505, United States

  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

    Mechanicsburg, Pennsylvania, 17050, United States

  • UPMC Hillman Cancer Center in Coraopolis

    Moon Township, Pennsylvania, 15108, United States

  • UPMC Memorial

    York, Pennsylvania, 17408, United States

  • UPMC Pinnacle Cancer Center/Community Osteopathic Campus

    Harrisburg, Pennsylvania, 17109, United States

  • UPMC Uniontown Hospital Radiation Oncology

    Uniontown, Pennsylvania, 15401, United States

  • UPMC Washington Hospital Radiation Oncology

    Washington, Pennsylvania, 15301, United States

  • UPMC-Heritage Valley Health System Beaver

    Beaver, Pennsylvania, 15009, United States

  • UPMC-Johnstown/John P. Murtha Regional Cancer Center

    Johnstown, Pennsylvania, 15901, United States

  • UPMC-Magee Womens Hospital

    Pittsburgh, Pennsylvania, 15213, United States

  • UPMC-Passavant Hospital

    Pittsburgh, Pennsylvania, 15237, United States

  • UPMC-Saint Clair Hospital Cancer Center

    Pittsburgh, Pennsylvania, 15243, United States

  • UPMC-Saint Margaret

    Pittsburgh, Pennsylvania, 15215, United States

  • UPMC-Shadyside Hospital

    Pittsburgh, Pennsylvania, 15232, United States

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • UT Southwestern Clinical Center at Richardson/Plano

    Richardson, Texas, 75080, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • Unity Hospital

    Fridley, Minnesota, 55432, United States

  • University Medical Center New Orleans

    New Orleans, Louisiana, 70112, United States

  • University of Arizona Cancer Center-North Campus

    Tucson, Arizona, 85719, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Cincinnati Cancer Center-UC Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Cincinnati Cancer Center-West Chester

    West Chester, Ohio, 45069, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

  • University of Kansas Cancer Center - Lee's Summit

    Lee's Summit, Missouri, 64064, United States

  • University of Kansas Cancer Center - North

    Kansas City, Missouri, 64154, United States

  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas, 66210, United States

  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas, 66205, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Michigan - Brighton Center for Specialty Care

    Brighton, Michigan, 48116, United States

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan, 48912, United States

  • University of Michigan Health - West

    Wyoming, Michigan, 49519, United States

  • University of Michigan Rogel Cancer Center

    Ann Arbor, Michigan, 48109, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Texas Medical Branch

    Galveston, Texas, 77555-0565, United States

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195, United States

  • Valley Medical Center

    Renton, Washington, 98055, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Vince Lombardi Cancer Clinic - Oshkosh

    Oshkosh, Wisconsin, 54904, United States

  • Vince Lombardi Cancer Clinic-Sheboygan

    Sheboygan, Wisconsin, 53081, United States

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin, 54241, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Weisberg Cancer Treatment Center

    Farmington Hills, Michigan, 48334, United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan, 49007, United States

  • West Virginia University Healthcare

    Morgantown, West Virginia, 26506, United States

  • Western Illinois Cancer Treatment Center

    Galesburg, Illinois, 61401, United States

  • Woodland Memorial Hospital

    Woodland, California, 95695, United States

  • Yale University

    New Haven, Connecticut, 06520, United States

  • Yale-New Haven Hospital North Haven Medical Center

    North Haven, Connecticut, 06473, United States

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