A new twist on rehab: could restricted blood flow boost balance and joint awareness?
NCT ID NCT07750106
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests whether adding blood flow restriction (BFR) training to standard physical therapy improves balance and joint position sense in post-menopausal women with posterior tibial tendon dysfunction (PTTD), a common cause of foot pain and flatfoot. Fifty-four women aged 40-55 with early-stage PTTD will be randomly assigned to either BFR training or conventional exercises. Researchers will measure changes in postural stability and ankle joint awareness before and after the program to see if BFR offers extra benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Blood flow restriction (BFR) training using a pneumatic cuff during low-load resistance exercise, compared with conventional physical therapy
- What this could lead to
- If effective, BFR training could become a standard addition to rehabilitation for posterior tibial tendon dysfunction, improving balance and reducing fall risk in post-menopausal women.
- What could go wrong
- This is a small, early-stage trial, and the benefits may not be large or lasting. BFR training carries risks like muscle soreness or rare blood clots, and results may not apply beyond this specific group.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 54 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 55 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female post-menopausal women aged 40-55 years. * Clinically diagnosed with Stage I or flexible Stage II posterior tibial tendon dysfunction according to the Johnson and Strom classification modified by Myerson confirmed by an orthopedic physician. * Symptoms persisting for ≥ 3 months. * Pain intensity of ≥3/10 on the Visual Analogue Scale (VAS) during weight-bearing activities. * Medically cleared to participate in blood flow restriction resistance training. * Symptoms located at the medial ankle or foot. * Pain on palpation of the posterior tibial tendon. * A positive double and/or single heel-rise test. * Able to walk independently without assistive devices * Body Mass Index (BMI) between 18.5 and \<24.9 kg/m². * Willingness to participate and provide written informed consent. Exclusion Criteria: * Rigidity of the hindfoot. * Pain on palpation of the fibular muscles. * History of corticosteroid injection in the tendon in a one-month period prior to the study onset. * History of surgery to the hindfoot and/or ankle. * History of previous surgeries to the musculoskeletal structures (i.e., bones, joint structures, nerves) in either limb of the lower extremities. * History of a fracture in either limb of the lower extremities requiring realignment. * Acute injury to musculoskeletal structures of other joints of the lower extremity in the previous three months, which impacted joint integrity and function (i.e., sprains, fractures) resulting in interruption of desired physical activity. * Hip joint or knee joint replacement. * Patients who were possibly at risk of adverse reactions of blood flow restriction (i.e., poor circulatory system, obesity, diabetes, arterial calcification, sickle cell trait, severe hypertension, or renal failure). * Any neurological conditions that affect proprioception, such as polyneuropathy, multiple sclerosis, and sensory ataxia. * Vestibular deficits and vision problems.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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Contacts and locations
Locations
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Faculty of Physical Therapy, May University in Cairo
Cairo, Cairo Governorate, Egypt
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