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A new twist on rehab: could restricted blood flow boost balance and joint awareness?

NCT ID NCT07750106

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether adding blood flow restriction (BFR) training to standard physical therapy improves balance and joint position sense in post-menopausal women with posterior tibial tendon dysfunction (PTTD), a common cause of foot pain and flatfoot. Fifty-four women aged 40-55 with early-stage PTTD will be randomly assigned to either BFR training or conventional exercises. Researchers will measure changes in postural stability and ankle joint awareness before and after the program to see if BFR offers extra benefits.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood flow restriction (BFR) training using a pneumatic cuff during low-load resistance exercise, compared with conventional physical therapy
What this could lead to
If effective, BFR training could become a standard addition to rehabilitation for posterior tibial tendon dysfunction, improving balance and reducing fall risk in post-menopausal women.
What could go wrong
This is a small, early-stage trial, and the benefits may not be large or lasting. BFR training carries risks like muscle soreness or rare blood clots, and results may not apply beyond this specific group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 55 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female post-menopausal women aged 40-55 years. * Clinically diagnosed with Stage I or flexible Stage II posterior tibial tendon dysfunction according to the Johnson and Strom classification modified by Myerson confirmed by an orthopedic physician. * Symptoms persisting for ≥ 3 months. * Pain intensity of ≥3/10 on the Visual Analogue Scale (VAS) during weight-bearing activities. * Medically cleared to participate in blood flow restriction resistance training. * Symptoms located at the medial ankle or foot. * Pain on palpation of the posterior tibial tendon. * A positive double and/or single heel-rise test. * Able to walk independently without assistive devices * Body Mass Index (BMI) between 18.5 and \<24.9 kg/m². * Willingness to participate and provide written informed consent. Exclusion Criteria: * Rigidity of the hindfoot. * Pain on palpation of the fibular muscles. * History of corticosteroid injection in the tendon in a one-month period prior to the study onset. * History of surgery to the hindfoot and/or ankle. * History of previous surgeries to the musculoskeletal structures (i.e., bones, joint structures, nerves) in either limb of the lower extremities. * History of a fracture in either limb of the lower extremities requiring realignment. * Acute injury to musculoskeletal structures of other joints of the lower extremity in the previous three months, which impacted joint integrity and function (i.e., sprains, fractures) resulting in interruption of desired physical activity. * Hip joint or knee joint replacement. * Patients who were possibly at risk of adverse reactions of blood flow restriction (i.e., poor circulatory system, obesity, diabetes, arterial calcification, sickle cell trait, severe hypertension, or renal failure). * Any neurological conditions that affect proprioception, such as polyneuropathy, multiple sclerosis, and sensory ataxia. * Vestibular deficits and vision problems.

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Conditions

The condition(s) this trial relates to.

Posterior Tibial Tendon Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Physical Therapy, May University in Cairo

    Cairo, Cairo Governorate, Egypt

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