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New bowel prep could boost colonoscopy success in cirrhosis patients

NCT ID NCT07668778

Disease control Sponsor: Hospital do Divino Espírito Santo de Ponta Delgada Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a laxative (bisacodyl) and a longer low-fiber diet to the standard bowel prep improves colonoscopy quality in people with cirrhosis. About 252 adults will be randomly assigned to either the standard or modified prep. The goal is to see if the new approach leads to better colon cleaning and higher detection of polyps or cancer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
polyethylene glycol (PEG) plus bisacodyl
What this could lead to
If it works, this could provide a safer, more effective bowel preparation method for people with cirrhosis, improving colonoscopy quality and colorectal cancer detection.
What could go wrong
This is a Phase 3 trial, but it hasn't started recruiting yet. The modified regimen may not significantly improve outcomes and could cause more side effects like cramping or dehydration.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 252 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Established diagnosis of cirrhosis, scheduled for elective outpatient total colonoscopy * Age ≥ 18 years * Ability to follow verbal and written instructions in Portuguese Exclusion Criteria: * Urgent procedures * Colonoscopies not intended to reach the caecum * History of any colonic surgery * Absolute contraindication to bowel preparation or colonoscopy * Active hepatic encephalopathy (West Haven grade ≥2) at the time of enrolment * Refractory ascites, defined as ascites unresponsive to maximum diuretic therapy or requiring repeated large-volume paracentesis * Severe hyponatraemia (serum sodium \<125 mEq/L) at the time of enrolment * Subject refusal or inability to comprehend the trial

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver Fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bowel preparation Cirrhosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital Central do Funchal, SESARAM

    Funchal, Madeira, 9004-514, Portugal

  • Hospital do Divino Espírito Santo de Ponta Delgada

    Ponta Delgada, São Miguel, 9500-370, Portugal

  • ULS da Arrábida

    Setúbal, 2910-446, Portugal

  • ULS de Coimbra

    Coimbra, 3004-561, Portugal

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