Can blueberries soothe inflammation in seniors with the blues?
NCT ID NCT05937165
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested whether freeze-dried blueberry powder can boost flavonoid levels and reduce inflammation in older adults with mild depressive symptoms. Six participants aged 65 and older consumed either a standard or higher dose of blueberry powder for three days. Researchers measured changes in urine flavonoids and blood markers of inflammation like C-reactive protein.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Freeze-dried blueberry powder
- What this could lead to
- If successful, this could point toward a dietary approach to reduce inflammation linked to depression in older adults.
- What could go wrong
- This is a very small pilot study with only 6 participants, so results may not apply broadly. It only looks at short-term effects, not long-term benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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6 people
The number who actually took part.
- Started
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Oct 2023
- Finished
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Nov 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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65 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men and women aged 65 years and older * Minor levels of depressive symptoms (center for epidemiological studies depression scale, ≥4 and \<16 points) Exclusion Criteria\*: * Unwilling to follow the study protocol * Cognitive impairment (assessed via the telephone Montreal Cognitive Assessment) defined as individuals scoring \<19) * Self-reporting a history of major depression, bipolar, schizophrenia, or other psychotic or neurologic disorders * Self-reporting of history gastro-intestinal diseases/conditions e.g., of bowel resection, inflammatory bowel disease/syndrome, Celiac disease * Self-reporting immune disorders, e.g., rheumatoid arthritis, cancer, and other immunocompromising conditions * Self-reporting history of type 1 or type 2 diabetes * Self-reporting any history of substance or alcohol use disorder * Allergy to blueberries * Self-reporting use of anti-inflammatory (e.g., fish oil or non-steroidal anti-inflammatory drugs) or immune-suppressant drugs * Are excessive tea or coffee consumers (e.g., \>3 cups/day) * Recent and consistent use of antibiotics * Currently taking or advised during the intervention to take anti-depressants * Current homicidal or suicidal ideation (assessed via the P4 Suicidality Screener * All deviations must be approved by the study sponsor
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hebrew Rehabilitation Center
Roslindale, Massachusetts, 02131, United States
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