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Can blueberries soothe inflammation in seniors with the blues?

NCT ID NCT05937165

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether freeze-dried blueberry powder can boost flavonoid levels and reduce inflammation in older adults with mild depressive symptoms. Six participants aged 65 and older consumed either a standard or higher dose of blueberry powder for three days. Researchers measured changes in urine flavonoids and blood markers of inflammation like C-reactive protein.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Freeze-dried blueberry powder
What this could lead to
If successful, this could point toward a dietary approach to reduce inflammation linked to depression in older adults.
What could go wrong
This is a very small pilot study with only 6 participants, so results may not apply broadly. It only looks at short-term effects, not long-term benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

6 people

The number who actually took part.

Started

Oct 2023

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged 65 years and older * Minor levels of depressive symptoms (center for epidemiological studies depression scale, ≥4 and \<16 points) Exclusion Criteria\*: * Unwilling to follow the study protocol * Cognitive impairment (assessed via the telephone Montreal Cognitive Assessment) defined as individuals scoring \<19) * Self-reporting a history of major depression, bipolar, schizophrenia, or other psychotic or neurologic disorders * Self-reporting of history gastro-intestinal diseases/conditions e.g., of bowel resection, inflammatory bowel disease/syndrome, Celiac disease * Self-reporting immune disorders, e.g., rheumatoid arthritis, cancer, and other immunocompromising conditions * Self-reporting history of type 1 or type 2 diabetes * Self-reporting any history of substance or alcohol use disorder * Allergy to blueberries * Self-reporting use of anti-inflammatory (e.g., fish oil or non-steroidal anti-inflammatory drugs) or immune-suppressant drugs * Are excessive tea or coffee consumers (e.g., \>3 cups/day) * Recent and consistent use of antibiotics * Currently taking or advised during the intervention to take anti-depressants * Current homicidal or suicidal ideation (assessed via the P4 Suicidality Screener * All deviations must be approved by the study sponsor

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Conditions

The condition(s) this trial relates to.

Depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hebrew Rehabilitation Center

    Roslindale, Massachusetts, 02131, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.