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Beet juice shows promise for heart and lung health in small study

NCT ID NCT04920799

Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether drinking beet juice twice daily for two weeks could improve blood vessel function and breathing muscle strength in older adults with coronary artery disease. Eight participants were randomly assigned to receive either nitrate-rich beet juice or a placebo version, then switched after a break. The main goal was to see if a larger trial is feasible, not to prove effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
beetroot juice (nitrate-rich)
What this could lead to
If it works, this could point toward a simple dietary supplement to support heart and breathing health in older adults with coronary artery disease.
What could go wrong
This is a very small pilot study with only 8 participants, designed mainly to test feasibility. Results may not apply to everyone, and any benefits need confirmation in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

8 people

The number who actually took part.

Started

Nov 2021

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults with coronary artery disease (CAD) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization. * Considered to have stable CAD on optimal medical therapy * 60 to 85 years of age * Males and females (females must be postmenopausal either natural or surgical) * Able to give consent Exclusion Criteria: * Unstable angina, recent myocardial infarction or heart failure within 6 months * Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months. * Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant ongoing or recurrent illness * Individuals who have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months * Uncontrolled hypertension * Use of tobacco products including smoking traditional or e-cigarettes * Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone) * Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation * Unwilling to remain weight stable during study participation

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease

Contacts and locations

Locations

  • Integrative Cardiovascular Physiology Laboratory, University of Florida

    Gainesville, Florida, 32611, United States

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Other studies related to the condition(s) this trial covers.