Mind-Controlled glove could help stroke survivors move their hands again
NCT ID NCT06076928
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests a wearable robotic glove that reads brain signals to help people who have had a stroke move their hand and arm. Sixty participants will be split into three groups: one using the brain-controlled glove, one using the glove without brain control, and one receiving standard therapy. The goal is to see if the brain-controlled glove improves hand function better than current treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Brain-computer interface integrated wearable hand robotic glove
- What this could lead to
- If it works, this could offer a new way to improve hand and arm function after a stroke, helping people regain independence.
- What could go wrong
- This is an early pilot study with only 60 people, so results may not apply to everyone. The device is experimental and may not work better than existing therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2024
- Expected to finish
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Jan 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 21-85 years, males and females 2. First diagnosis of stroke (ischemic or haemorrhagic), confirmed by neurologist/neurosurgeon/CT/MRI imaging 3. \> 16 weeks post stroke 4. Hemiplegic pattern of post-stroke weakness 5. MRC ≥ 2/5 motor power and above for shoulder abduction \& elbow flexion 6. MRC 0 to 4/5 motor power and above for finger flexors \&/or extensors of thumb, index, middle fingers 7. Screening Fugl-Meyer wrist hand sub score \<18/24 8. Spasticity MAS \<3 for thumb, index, and middle fingers 9. Able to discriminate thumb and index sensation to pain 10. Hand sizes within 170-200mm (length) \&75-85mm (width), compatible with HandyRehab robotic glove 11. BCI compatible brain states using a standardised screening protocol 12. Able to understand simple commands with Mini Mental state examination scores MMSE \> 21/30) 13. Able to give informed consent * Subjects who are unable to clear BCI screening 11. will be randomised to either CT or HR groups. Exclusion Criteria: Neurological * Recurrent stroke * Diagnosis of neurodegenerative disease; e.g. Parkinson's' disease, Dementia, ALS Medical: \- unstable medical or neurological conditions, life expectancy \<6 months, end-organ renal failure on dialysis, severe heart failure, postural hypotension, history of uncontrolled sepsis, epilepsy with seizure within 3 months of informed consent, skin conditions which could potentially be worsened by wearable robot (ulcers, open wounds, eczema, infections etc) Postural: * Unable to tolerate upright posture or sit unaided for \< 90min with rest breaks * Cognitive/behavioural/visual: * Severe dysphasia/aphasia, severe visual neglect/blindness, untreated severe depression, psychiatric illness, unable to understand study requirements Upper limb: * Moderate to severe spasticity (Modified Ashworth scale MAS ≥2) * Hand/arm related pain (VAS Pain ≥ 5/10), * Presence of finger contractures, reduced functional range of motion, limiting functional wrist/finger movements, active fractures or arthritis with deformities * Severe limb ataxia/apraxia * Severe post stroke hemi-anaesthesia in affected UE BCI incompatibility: * Motor imagery EEG signals unable to be detected * Presence of craniectomy skull defect (affecting BCI cap fit and electrode contact) * Concomitant participation in other interventional research trials * Resident of nursing home or overseas country which may compromise attendance at research site * Pregnant or lactating females will not be allowed to participate
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Tan Tock Seng Hospital
RECRUITINGSingapore, Singapore, 308433, Singapore
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a checklist and heart monitor stop repeat strokes?
- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next
- Zapping the spine while wearing a robotic ankle: a new way to help kids walk?
- Can a nurse and a neighbor help tame chronic disease?
- Can PET scans reveal hidden heart inflammation after a stroke?
- Two ways to catch a hidden heart rhythm after stroke