New hope for stubborn low platelets after transplant?
NCT ID NCT07535645
First seen Jun 27, 2026 · Last updated Sep 17, 2026 · Updated 2 times
Summary
This study tests the drug baricitinib in 28 adults who have dangerously low platelet counts after a stem cell transplant and did not improve with standard treatments. The goal is to see if baricitinib can safely raise platelet levels enough to reduce the need for transfusions. The study is in early phases (1b/2) and is not yet recruiting.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 28 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Sep 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18-70 years; * Underwent allo-HSCT; * Meet the diagnostic criteria for delayed platelet engraftment (DPE) or secondary failure of platelet recovery (SFPR); * Have platelet counts consistently \<20 ×10\^9/L or transfusion-dependent within 14 days prior to enrollment; * Have received adequate corticosteroid and TPO-RA therapy for persistent thrombocytopenia for no less than 4 weeks, with treatment failure or intolerance; * Complete donor chimerism. Exclusion Criteria: * Relapse of hematologic malignancy or MRD positivity; * Active infection; * Active graft-versus-host disease; * Thrombotic microangiopathy; * Primary graft failure or poor graft function; * Presence of other factors that may lead to secondary thrombocytopenia at the time of PT diagnosis; * History of systemic herpes zoster infection within 12 weeks prior to enrollment screening; * Acute or chronic infection with HBV, HCV, or HIV; * Evidence of active tuberculosis, or history of active tuberculosis without documented standard anti-tuberculosis treatment, or close contact with active tuberculosis without documented standard tuberculosis prophylaxis; * Receipt of a live vaccine within 12 weeks prior to enrollment screening, or planned receipt of a live vaccine during the study period; * Clinically significant thromboembolic event within 24 weeks prior to enrollment screening, or current use of anticoagulant medications deemed by the investigator to carry an uncontrollable risk; * Estimated glomerular filtration rate \<50 mL/min/1.73 m\^2; * Severe pre-existing or current conditions involving the cardiovascular, respiratory, hepatic, gastrointestinal, endocrine, nervous, or neuropsychiatric systems, or other severe or unstable illnesses or laboratory abnormalities that will make the study drug unacceptable for the patient or can interfere study data; * Participation in another clinical trial within 30 days prior to enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Peking University People's Hospital
RECRUITINGBeijing, Beijing Municipality, 100044, China
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Other studies related to the condition(s) this trial covers.
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- Can a Low-Dose antifungal shield vulnerable patients from deadly fungal infections?
- Could a simple drug infusion stop a dangerous virus after stem cell transplants?
- Study to reveal if younger donors boost transplant success
- Can donor t cells beat a tough virus after transplant? new trial aims to find out.