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Can gentle balance challenges help stroke survivors walk better?

NCT ID NCT05110300

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding safe balance challenges (called perturbations) to body-weight supported walking therapy helps stroke survivors improve their balance and walking more than standard therapy alone. Participants were adults in inpatient rehab after a stroke. They used a robotic harness system (ZeroG) that prevents falls while walking. Some received standard therapy, while others also experienced gentle pushes or pulls during exercises. The study was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Body weight support system with balance perturbations (ZeroG TRiP)
What this could lead to
If it works, this approach could help stroke survivors regain balance and walking ability more effectively than standard therapy.
What could go wrong
The trial was terminated early, so results are limited. It is a small, early-stage study, and the added perturbations may not provide extra benefit over standard body-weight support.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

114 people

The number who actually took part.

Started

Dec 2021

Finished

Nov 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Admitted to one of the listed study locations for inpatient rehabilitation following a stroke. * Be 18 years of age or older. * Have at least a moderate fall risk or better, shown by an admission Berg Balance Scale (BBS) score of 21/56 or greater. * Patients that score below 21 or are non-ambulatory will not be considered for this study. * Patients that are emergently re-admitted to acute care and subsequently re-admitted to the stroke rehabilitation program will be reassessed for appropriateness of continuation in the study on a case by case basis. * Patients that progress to a BBS score of 21 or greater during their stay, and have a set discharge date of 10 days or longer, can be approached for study recruitment. * Appropriate cognition * Able to read and understand the consent, in English or a language available by translator services, based on the judgement of the clinical team, either by using outcomes measures, i.e. SLUMS greater than or equal to 20, or through clinical evaluations and team discussion. Eligibility will ultimately be decided by the treating physician in combination with the participant's clinical team. * Ability to tolerate and actively participate in up to six, 30-minute sessions, with physical therapy while using the BWSS. * Weigh less than 450 pounds, per the structural limitations of the ZeroG system. Exclusion Criteria: * Active seizures * Spinal stabilization with the use of Halos * Uncontrolled hypertension or hypotension * Unstable skin structures (i.e. skin grafts) * Chest tubes * Unstable rib or lower extremity fractures * Severe osteoporosis * Participants where pressure around the abdomen, thighs, groin, or shoulders in contraindicated * Cognitive deficits that would disrupt the ability to provide informed consent as described above * Active enteric infection control precautions * Subjects would be eligible once precautions are lifted * Ongoing orthostasis * New limb amputations * Vestibular disorders that may impact balance * Premorbid conditions that may impact balance * Patients requiring more than 50% high flow oxygen as consistent with inpatient therapy guidelines * Anyone belonging to a vulnerable population, including inmates, individuals under the age of 18, and who are or might be pregnant

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Conditions

The condition(s) this trial relates to.

Gait Disorders, Neurologic stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Gaylord Hospital

    Wallingford, Connecticut, 06492, United States

  • MedStar National Rehabilitation Hospital

    Washington D.C., District of Columbia, 20010, United States

  • Providence St. Luke's Rehabilitation Medical Center

    Spokane, Washington, 99202, United States

  • Spaulding Rehabilitation Hospital

    Sandwich, Massachusetts, 02537, United States

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