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Common antibiotic may speed remission in kids with kidney disease

NCT ID NCT07320612

Disease control Sponsor: University of Child Health Sciences and Children's Hospital, Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding the antibiotic azithromycin to standard steroid treatment helps children with steroid-sensitive nephrotic syndrome achieve remission faster. 160 children aged 2 to 14 were split into two groups: one received azithromycin plus steroids, the other only steroids. The goal was to see if the combination led to earlier remission and fewer relapses.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
azithromycin
What this could lead to
If it works, this could point toward a way to help children with nephrotic syndrome reach remission faster and have fewer relapses.
What could go wrong
This is an early phase 1 trial, so results are preliminary. The addition of azithromycin may not improve outcomes and could cause side effects like heart rhythm issues or infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

160 people

The number who actually took part.

Started

Mar 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 14 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children age 2 to 14 years * Both genders * Children having primary nephrotic syndrome Exclusion Criteria: * Children with steroid resistant nephrotic syndrome * Children with secondary causes of nephrotic syndrome * Recent use of azithromycin during last 4 weeks * Severe systemic infection requiring antibiotics * Chronic liver disease Prolong QT Interval or history of cardiac arythmias

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Conditions

The condition(s) this trial relates to.

nephrotic syndrome nephrotic syndrome of childhood - steroid sensitive

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nephrotic syndrome

Contacts and locations

Locations

  • UCHS

    Lahore, Punjab Province, 54600, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.