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New drug targets genetic weakness in Hard-to-Treat cancers

NCT ID NCT04439123

First seen Nov 18, 2025 · Last updated Jun 15, 2026 · Updated 24 times

Summary

This study tests a drug called AZD5363 in 35 adults whose cancers have a specific genetic change (AKT mutation). The drug blocks a protein that helps cancer cells grow. Researchers want to see if it can shrink tumors or stop them from growing. Participants have advanced solid tumors, lymphoma, or multiple myeloma that haven't responded to other treatments.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ECOG-ACRIN Cancer Research Group

    Philadelphia, Pennsylvania, 19103, United States

Conditions

The condition(s) this trial relates to.

cancer hematopoietic and lymphoid system neoplasm lymphoma plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.