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Can activating cell cleanup improve blood vessel function in diabetes?

NCT ID NCT05593549

Knowledge-focused Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a natural cell process called autophagy (cell cleanup) is reduced in people with type 2 diabetes and if that harms small blood vessels. Sixty adults with and without diabetes will take either trehalose (a sugar that may boost autophagy) or a placebo for 14 days. Researchers will measure blood vessel function and autophagy markers to understand the link.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants must be between 18-80 yrs. of age and will be delineated into two groups * Clinical Diagnosis of Type 2 Diabetes Mellitus in accordance with American Diabetes Association (ADA) guidelines (Type 2 Diabetic group) * Otherwise healthy individuals (Healthy control group) with no more than 1 cardiovascular risk factor Exclusion Criteria: * Uncontrolled hypertension * Current Tobacco use or within last 6 months * BMI \> 35 * Hyperlipidemia * Hypercholesterolemia * Type 1 Diabetes * Use of anti-coagulant drugs, or anti-platelet drugs * Symptomatic coronary artery disease * Heart Failure * Renal Impairment * Hormone Replacement Therapy * History of Retinopathy * Documented Neuromuscular Disorders * Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity) * Pregnancy (Young Female subjects) * Allergies to Povidone Iodine * Use Erectile Dysfunction Medication in the past 6 months * Use of Topical/non-topical Steroids in last 6 months * Active Anti-Cancer Treatment or Treatment within last 12 months * Active COVID-19 or within the past 3 months * Gender Reassignment Therapy

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy aging Type 2 diabetes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

More trials for these conditions

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