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Hormone clues: could a simple diet test unlock secrets of high blood pressure?

NCT ID NCT03484130

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study follows 100 adults aged 35-70 with mildly elevated blood pressure to see how their aldosterone hormone system changes over time. Participants will eat special high-salt or low-salt diets for a few days each year to test how their body responds. The goal is to better understand a condition called autonomous aldosterone secretion, which may contribute to high blood pressure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better understand and identify early hormone-related causes of high blood pressure, potentially leading to more targeted treatments.
What could go wrong
This is an observational study, not testing a new treatment. It is small (100 participants) and early-stage, so findings may not apply to everyone or lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2018

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Normotensive individuals who have a reasonably high risk of developing hypertension in the next few years

Ages

35 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 35-70 years 2. Systolic blood pressure of 120-135 mmHg and/or diastolic blood pressure of 75-85 mmHg 3. At least one, or more, of the following: * BMI ≥ 25 kg/m2 * Family history of hypertension prior to the age of 60 years in a parent or sibling * Diabetes with a hemoglobin A1c \< 9% 4. If systolic blood pressure 115-135 mmHg and/or diastolic blood pressure 70-85 mmHg, must have two or more of the following: * BMI ≥ 25 kg/m2 * Family history of hypertension prior to the age of 60 years in a parent or sibling * Diabetes with a hemoglobin A1c \< 9% Exclusion Criteria: * Known history of hypertension or use of antihypertensive medications * Known history of stroke, coronary artery disease, myocardial infarction, heart failure, cerebral or aortic aneurysm, or preeclampsia. * Active cancer that is being treated with chemotherapeutic agents * Pregnancy * Breast feeding * Daily use of prescribed opioid medications * Illicit drug use (cocaine, heroin, methamphetamine) * Daily non-steroidal anti-inflammatory medication use * Daily use of glucocorticoids * Electrocardiogram that shows evidence of prior myocardial infarction, atrial arrhythmia, left or right bundle branch blocks. * Estimated glomerular filtration rate \< 60 mL/min/1.73m2 * Active and untreated hyper- or hypo-thyroidism * Abnormal screening laboratories (comprehensive metabolic panel, complete blood count, thyrotropin) * BMI ≥ 45 kg/m2

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Conditions

The condition(s) this trial relates to.

adrenal gland disorder hyperaldosteronism hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adrenal gland disease Aldosterone disorder Blood pressure

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.