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Scientists use Mini-Brains to unlock Autism's secrets

NCT ID NCT07494331

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study aims to understand the biological causes of autism by growing tiny 3D brain models called organoids from cells of people with autism. Researchers will compare these organoids to those from siblings without autism to see how genetic differences affect brain cell development. The goal is to uncover the mechanisms behind autism, which could lead to better treatments in the future. The study involves 80 participants, including children with autism, their siblings, and parents.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal how genetic changes lead to autism, pointing toward future treatments.
What could go wrong
This is an early-stage observational study using lab-grown organoids, not a treatment trial. Findings may not directly translate to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

A child with an autism spectrum disorder, a sibling over the age of 2 who does not have an autism spectrum disorder, and biological parents

Ages

2 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A child diagnosed with an autism spectrum disorder in accordance with clinical practice guidelines * A sibling without an autism spectrum disorder (SRS \< 65) * Biological parents * Children and parents must be enrolled in a social security program, Universal Health Coverage (CMU), or an equivalent program. Exclusion Criteria: * Refusal to undergo a blood test * Uncontrolled (unstabilized) medical condition (including psychiatric conditions) that precludes participation in the study * Sibling with an SRS score \> 65 at screening or under 2 years old

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autism spectrum disorder (ASD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Robert Debré Hospital

    Paris, 75019, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.